Aykut Erbas
@erbash.bsky.social
P.I. @bilkentunam @BilkentUniv
Previously@NorthwesternU,@UNC,@TU_Muenchen,@kocuniversity,@itu1773
Molecular bio/polymer/physicist
Previously@NorthwesternU,@UNC,@TU_Muenchen,@kocuniversity,@itu1773
Molecular bio/polymer/physicist
Read more 👉 pubs.aip.org/aip/jcp/arti...
#CellBiology #Laminopathies #HGPS #NuclearMechanics #Research #Biophysics
#CellBiology #Laminopathies #HGPS #NuclearMechanics #Research #Biophysics
Phase behavior and dissociation kinetics of lamins in a polymer model of progeria
One of the key structural proteins in the eukaryotic cell nucleus is lamin. Lamins can assemble into a two-dimensional protein meshwork at the nuclear periphery
pubs.aip.org
May 9, 2025 at 11:27 AM
we uncover how changes in lamin-lamin and lamin-INM interaction could drive the emergence of abnormal lamin phases that can appear in laminopathies. These findings hint at how competition between various physical interactions can affect lamina and maybe drive disease progression.
Phase behavior and dissociation kinetics of lamins in a polymer model of progeria
One of the key structural proteins in the eukaryotic cell nucleus is lamin. Lamins can assemble into a two-dimensional protein meshwork at the nuclear periphery
pubs.aip.org
May 9, 2025 at 11:27 AM
we uncover how changes in lamin-lamin and lamin-INM interaction could drive the emergence of abnormal lamin phases that can appear in laminopathies. These findings hint at how competition between various physical interactions can affect lamina and maybe drive disease progression.
Our recent study (using a minimal molecular dynamics model) investigates how lamin concentration and affinity interactions dictate the formation of these dense nematic domains, affecting dissociation dynamics. By modeling lamin fibers as rod-like polymer chains,
Phase behavior and dissociation kinetics of lamins in a polymer model of progeria
One of the key structural proteins in the eukaryotic cell nucleus is lamin. Lamins can assemble into a two-dimensional protein meshwork at the nuclear periphery
pubs.aip.org
May 9, 2025 at 11:27 AM
Our recent study (using a minimal molecular dynamics model) investigates how lamin concentration and affinity interactions dictate the formation of these dense nematic domains, affecting dissociation dynamics. By modeling lamin fibers as rod-like polymer chains,