Emil Gustavsson
@emilgustavsson.bsky.social
Staff #scientist in the Landau group (https://landau-lab.de) at CSSB/DESY, structural biologist studying functional #amyloids using #cryoEM.
Climbing in my spare time.
🇸🇪 in 🇩🇪
Climbing in my spare time.
🇸🇪 in 🇩🇪
We also observed OBP bound to a DNA hairpin with a single-stranded tail, an intermediate state in the DNA unwinding. Here OBP switches from dimer to monomer, revealing dramatic conformational flexibility during origin activation.
For more details, check out our paper here 👉 doi.org/10.1093/nar/...
For more details, check out our paper here 👉 doi.org/10.1093/nar/...
October 23, 2025 at 6:44 AM
We also observed OBP bound to a DNA hairpin with a single-stranded tail, an intermediate state in the DNA unwinding. Here OBP switches from dimer to monomer, revealing dramatic conformational flexibility during origin activation.
For more details, check out our paper here 👉 doi.org/10.1093/nar/...
For more details, check out our paper here 👉 doi.org/10.1093/nar/...
Furthermore, we can resolve a long-standing paradox: why C-terminal deletions enhance helicase activity but reduce replication efficiency? It turns out the C-terminal tail threads into the partner monomer in proximity to the ATP-binding pocket, regulating ATP hydrolysis and helicase activity.
October 23, 2025 at 6:43 AM
Furthermore, we can resolve a long-standing paradox: why C-terminal deletions enhance helicase activity but reduce replication efficiency? It turns out the C-terminal tail threads into the partner monomer in proximity to the ATP-binding pocket, regulating ATP hydrolysis and helicase activity.
We can show how the conserved RVKNL motif binds sequence-specifically to the HSV-1 origin of replication OriS. Our structures reveal that Lys758 and Arg783 are responsible for the discrimination between the three recognition sites (Box 1, 2 and 3) within OriS.
October 23, 2025 at 6:41 AM
We can show how the conserved RVKNL motif binds sequence-specifically to the HSV-1 origin of replication OriS. Our structures reveal that Lys758 and Arg783 are responsible for the discrimination between the three recognition sites (Box 1, 2 and 3) within OriS.
Using cryo-EM, we determined OBP structures at up to 2.8 Å resolution in multiple states:
1. bound to HSV-1 origin of replication (OriS) DNA
2. with a non-hydrolyzable ATP analog
3. as monomer, dimer, and higher-order assemblies
1. bound to HSV-1 origin of replication (OriS) DNA
2. with a non-hydrolyzable ATP analog
3. as monomer, dimer, and higher-order assemblies
October 23, 2025 at 6:40 AM
Using cryo-EM, we determined OBP structures at up to 2.8 Å resolution in multiple states:
1. bound to HSV-1 origin of replication (OriS) DNA
2. with a non-hydrolyzable ATP analog
3. as monomer, dimer, and higher-order assemblies
1. bound to HSV-1 origin of replication (OriS) DNA
2. with a non-hydrolyzable ATP analog
3. as monomer, dimer, and higher-order assemblies
Always a nice little autumn ritual watching the announcements
#NobelPrize
#NobelPrize
October 6, 2025 at 9:30 AM
Always a nice little autumn ritual watching the announcements
#NobelPrize
#NobelPrize
The only positive thing about spending the long weekend sick: Finally managed to build my very own Serenity in #nms
#Firefly
#youcanttaketheskyfromme
#Firefly
#youcanttaketheskyfromme
October 5, 2025 at 11:42 AM
The only positive thing about spending the long weekend sick: Finally managed to build my very own Serenity in #nms
#Firefly
#youcanttaketheskyfromme
#Firefly
#youcanttaketheskyfromme
Watching the climbing world championship is just about what I have the energy for this morning, after great but exhausting days of conference! 🧗♂️
September 27, 2025 at 9:26 AM
Watching the climbing world championship is just about what I have the energy for this morning, after great but exhausting days of conference! 🧗♂️
It is a wrap! Thank you to everyone who came and made this conference into such an amazing event.
#FFFatDESY2025
#FunctionalFibrilFriends
#amyloids
#FFFatDESY2025
#FunctionalFibrilFriends
#amyloids
September 26, 2025 at 12:31 PM
It is a wrap! Thank you to everyone who came and made this conference into such an amazing event.
#FFFatDESY2025
#FunctionalFibrilFriends
#amyloids
#FFFatDESY2025
#FunctionalFibrilFriends
#amyloids
We have officially opened!
#FFFatDESY2025
#FunctionalFibrilFriends
#amyloid
@cssbhamburg.bsky.social
@landaulabcssb.bsky.social
#FFFatDESY2025
#FunctionalFibrilFriends
#amyloid
@cssbhamburg.bsky.social
@landaulabcssb.bsky.social
September 24, 2025 at 12:04 PM
We have officially opened!
#FFFatDESY2025
#FunctionalFibrilFriends
#amyloid
@cssbhamburg.bsky.social
@landaulabcssb.bsky.social
#FFFatDESY2025
#FunctionalFibrilFriends
#amyloid
@cssbhamburg.bsky.social
@landaulabcssb.bsky.social
We are now less than a day away from the Functional Amyloid Meeting! Looking forward to amazing days in sunny Hamburg! 🧪🧬🧶
#FFFatDESY2025 #FunctionalFibrilFriends
#amyloids
@cssbhamburg.bsky.social
@landaulabcssb.bsky.social
@meytallandau.bsky.social
#FFFatDESY2025 #FunctionalFibrilFriends
#amyloids
@cssbhamburg.bsky.social
@landaulabcssb.bsky.social
@meytallandau.bsky.social
September 23, 2025 at 12:00 PM
We are now less than a day away from the Functional Amyloid Meeting! Looking forward to amazing days in sunny Hamburg! 🧪🧬🧶
#FFFatDESY2025 #FunctionalFibrilFriends
#amyloids
@cssbhamburg.bsky.social
@landaulabcssb.bsky.social
@meytallandau.bsky.social
#FFFatDESY2025 #FunctionalFibrilFriends
#amyloids
@cssbhamburg.bsky.social
@landaulabcssb.bsky.social
@meytallandau.bsky.social
Had an amazing weekend climbing with my brother in Stockholm, and managed to send my first 6a outdoors! Can't complain about the view at Ryssgraven either 🧗♂️
August 18, 2025 at 11:39 AM
Had an amazing weekend climbing with my brother in Stockholm, and managed to send my first 6a outdoors! Can't complain about the view at Ryssgraven either 🧗♂️
I'm generally for the European Union, but sometimes #EU make it really hard to be a supporter. Seems like #chatcontrol is up for debate again. This cannot be allowed to pass if we want to keep any resemblance of individual privacy. Contact your MEP:s, information available here: fightchatcontrol.eu
August 11, 2025 at 11:27 AM
I'm generally for the European Union, but sometimes #EU make it really hard to be a supporter. Seems like #chatcontrol is up for debate again. This cannot be allowed to pass if we want to keep any resemblance of individual privacy. Contact your MEP:s, information available here: fightchatcontrol.eu
Just a slight correction to the registration deadline 😉
August 1, 2025 at 12:55 PM
Just a slight correction to the registration deadline 😉
A new favorite kind of vacation! Even if 34 degrees was way too hot for climbing 🧗♂️🥵
July 2, 2025 at 9:21 AM
A new favorite kind of vacation! Even if 34 degrees was way too hot for climbing 🧗♂️🥵
It's hard to describe how amazing this conference has been, the final day had everything including a wedding, a boxing match and a great performance of Y.M.C.A. Thanks to all the organizers @woodstocknightsci.bsky.social, this has been a once-in-a-lifetime event!
#TCTeAC
#TCTeAC
June 13, 2025 at 6:03 AM
It's hard to describe how amazing this conference has been, the final day had everything including a wedding, a boxing match and a great performance of Y.M.C.A. Thanks to all the organizers @woodstocknightsci.bsky.social, this has been a once-in-a-lifetime event!
#TCTeAC
#TCTeAC
We're here, we read the fucking manual! 😉
June 12, 2025 at 6:47 AM
We're here, we read the fucking manual! 😉
Thanks for an amazing first day @woodstocknightsci.bsky.social
So much cool science, great walk-up songs, and creative performances such as songs about mantis shrimp photoreceptors, or rhyming your entire talk. Can't wait for tomorrow!
#TCTeAC
#theconferencetoendallconferences
So much cool science, great walk-up songs, and creative performances such as songs about mantis shrimp photoreceptors, or rhyming your entire talk. Can't wait for tomorrow!
#TCTeAC
#theconferencetoendallconferences
June 10, 2025 at 8:24 PM
Thanks for an amazing first day @woodstocknightsci.bsky.social
So much cool science, great walk-up songs, and creative performances such as songs about mantis shrimp photoreceptors, or rhyming your entire talk. Can't wait for tomorrow!
#TCTeAC
#theconferencetoendallconferences
So much cool science, great walk-up songs, and creative performances such as songs about mantis shrimp photoreceptors, or rhyming your entire talk. Can't wait for tomorrow!
#TCTeAC
#theconferencetoendallconferences
Germans: Beer HAVE to be brewed according to the Deutsche Reinheitsgebot!
Also Germans:
Also Germans:
June 4, 2025 at 6:36 PM
Germans: Beer HAVE to be brewed according to the Deutsche Reinheitsgebot!
Also Germans:
Also Germans:
Okay, so I'm not switching completely to #teamtomo
Helical reconstruction of #amyloids can be quite fun when you get beautiful structures like this!
And thanks to @sjorsscheres.bsky.social for the suggestion of higher order symmetries, it was indeed the case 😉🧪🧬🧶
Helical reconstruction of #amyloids can be quite fun when you get beautiful structures like this!
And thanks to @sjorsscheres.bsky.social for the suggestion of higher order symmetries, it was indeed the case 😉🧪🧬🧶
April 17, 2025 at 2:13 PM
Okay, so I'm not switching completely to #teamtomo
Helical reconstruction of #amyloids can be quite fun when you get beautiful structures like this!
And thanks to @sjorsscheres.bsky.social for the suggestion of higher order symmetries, it was indeed the case 😉🧪🧬🧶
Helical reconstruction of #amyloids can be quite fun when you get beautiful structures like this!
And thanks to @sjorsscheres.bsky.social for the suggestion of higher order symmetries, it was indeed the case 😉🧪🧬🧶
Spent the last two days learning FIB-milling with the Arctis, now I "only" need to have a good sample as well and we're in business! 😁 Soon-to-be #teamtomo
🧪🧬🧶
🧪🧬🧶
April 10, 2025 at 4:57 PM
Spent the last two days learning FIB-milling with the Arctis, now I "only" need to have a good sample as well and we're in business! 😁 Soon-to-be #teamtomo
🧪🧬🧶
🧪🧬🧶
Finally, I also managed to get my structures printed 😁
April 2, 2025 at 3:27 PM
Finally, I also managed to get my structures printed 😁
But they do form quite beautiful 2D classes 😉
March 6, 2025 at 2:31 PM
But they do form quite beautiful 2D classes 😉
Ahh, so we meet again dear reviewer
February 25, 2025 at 8:22 PM
Ahh, so we meet again dear reviewer