CASSIA is a multi-agent LLM–based tool for automatic, reference-free, and interpretable single-cell annotation. If you’ve struggled with manual annotation or found existing automatic tools unsatisfactory, CASSIA may be worth a try!

Link to the complete benchmark.

sc-llm-benchmark.com/methods/cassia

Whether you’re dissecting complex tissues or teasing out subtle cell states, CASSIA’s built to tackle the toughest challenges—transparently and efficiently.

Questions or thoughts? Let’s connect!
#Bioinformatics #SingleCell #RNAseq #CancerResearch #Immunology #OpenScience

CASSIA is fast: it processes 50 clusters in under a minute on a standard CPU. You only need 50 markers for balanced speed and detail—ideal for complex tissues and subtle cell states.