Huge thanks to our brilliant co-authors and the BACH Cohort study participants who made this possible! 💫

💡Interestingly, only some constructs were correlated, suggesting these composites could help isolate and probe distinct aspects of #brain health.

Many brain systems are functionally interconnected 🤝, making common biomarkers of in vivo brain health often broad or non-specific.

Using an agnostic, data-driven approach combining #MRI, #plasma biomarkers and #cardiovascular risk factors, we identified five underlying key constructs.

There’s growing evidence to suggest that in some pathologies, neurovascular integrity loss is one of the earliest measurable changes. However, it’s hard to say for sure whether this contributes to pathogenesis, or whether it is a result of existing pathology. It’s possibly a cycle of both!

Great question! Since measuring NVU integrity in vivo has its challenges, we are yet to be able to say which ‘breakdown’ typically happens first. In my opinion, it’s likely a bi-directional relationship, where dysfunction of an element of the NVU may affect waste clearance, but also vice versa.

Thanks for letting me know!
Sorry about that, try this one:

link.springer.com/article/10.1...

Very happy to chat all things CBF, including analysis and interpretations 😊

Big thank you to all the wonderful BACH Cohort Study participants, research team and co-authors who made this work possible! ✨

We interpret our findings within a #biological context, and discuss future directions for disentangling these coupled systems in #aging and disease.

🧠 We also show, for the first time, that cerebral blood flow is associated with water exchange through the #neurovascular unit, supporting the notion that vascular activity promotes fluid movement.

🧠 We observed associations between markers of fluid accumulation, likely reflecting a highly interconnected #brain waste clearance system.