Veeva axial.substack.com/p/axial-veeva

Veeva was founded in 2007 by Peter Gassner and Matt Wallach to make life sciences more efficient and bring new medicines to patients. The company is one of the most important case studies on how to build a standalone software business in life sciences.

Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins www.nature.com/articles/s41...

Deep Visual Proteomics defines single-cell identity and heterogeneity www.nature.com/articles/s41...

The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection www.science.org/doi/10.1126/...

"It's not enough what I did in the past - there is also the future"

- Rita Levi-Montalcini, Nobel Prize winner for discovering nerve growth factor

KRAS is vulnerable to reversible switch-II pocket engagement in cells www.nature.com/articles/s41...

"We believe that the last person in the door is just as important as the first. We consciously reject the German model for the Silicon Valley model. We want the guy on the loading dock to be thinking about clinical programs."

- Joshua Boger, Founder & CEO of Vertex Pharmaceuticals

Human chimeric antigen receptor macrophages for cancer immunotherapy www.nature.com/articles/s41...

Accelerating high-throughput virtual screening through molecular pool-based active learning pubs.rsc.org/en/content/a...

Applying Bayesian optimization to the problem of HTS by constructing a surrogate model of the docking score of a ligand for a given protein target

Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development www.nature.com/articles/ncb...

With 2 approaches, the paper estimates that there are approximately 30 HSC clones that arise during development in zebrafish. Similar to estimates in other animals

The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal and leukemia cells www.nature.com/articles/nm....

The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer www.cell.com/cell/pdf/S00...

Global profiling of phosphorylation-dependent changes in cysteine reactivity www.nature.com/articles/s41...

The paper studies how phosphorylation of proteins affects the reactivity of cysteine residues

www.pnas.org/doi/abs/10.1... The paper introduces Botryllus schlosseri, a marine colonial chordate, as a model organism for the study of neurodegeneration. As well as the evolutionary origins of these processes

Identifying and overcoming the sampling challenges in relative binding free energy calculations of a model protein:protein complex led by Ivy Zhang from the John Chodera lab www.biorxiv.org/content/10.1...

Image-based cell sorting using focused travelling surface acoustic waves

Describes a new method for sorting cells based on their physical properties. Using a combination of real-time deformability cytometry (RT-DC) and focused travelling surface acoustic waves (FTSAW).

pubs.rsc.org/en/content/a...

"Everything is made from a chemical reaction. If you look around my office, everything is made from a chemical reaction."

- David MacMillan, Nobel Prize winner for developing asymmetric organocatalysis