Elisa Xu
@elisaxu.bsky.social
Clinical Psych PhD student at Stony Brook University studying perception 👀 and interoception 🫀🧠 in psychopathology | Past: Research @ Center for Advanced Circuit Therapeutics @IcahnMountSinai | BA @Penn
🧵 10/ Big thanks to @sinaibrain.bsky.social and co-authors @allisonwatersphd.bsky.social @samanthapitts @jacobdahillfuchel @sarascherrer @tanyanauvel @jacquelineguerraoverton @patriciorivaposse @andreacrowell @martijnfigee @sankaralagapan @crozell.bsky.social @kisuengchoi.bsky.social
@helenmayberg
@helenmayberg
February 10, 2025 at 5:42 PM
🧵 10/ Big thanks to @sinaibrain.bsky.social and co-authors @allisonwatersphd.bsky.social @samanthapitts @jacobdahillfuchel @sarascherrer @tanyanauvel @jacquelineguerraoverton @patriciorivaposse @andreacrowell @martijnfigee @sankaralagapan @crozell.bsky.social @kisuengchoi.bsky.social
@helenmayberg
@helenmayberg
🧵 9/ A big thank you to our participants, team members, and funders (NIH, HDRF, NIMH) for making this research possible. 🙌 Explore the full study here: www.biologicalpsychiatrycnni.org/article/S245... #MentalHealth💡 #FriedmanBrainInstitute
Neural Interoceptive Processing Is Modulated by Deep Brain Stimulation to Subcallosal Cingulate Cortex for Treatment-Resistant Depression
Symptoms of depression are associated with impaired interoceptive processing of bodily
sensation. The antidepressant effects of subcallosal cingulate deep brain stimulation
(SCC DBS) include acute cha...
www.biologicalpsychiatrycnni.org
February 10, 2025 at 5:42 PM
🧵 9/ A big thank you to our participants, team members, and funders (NIH, HDRF, NIMH) for making this research possible. 🙌 Explore the full study here: www.biologicalpsychiatrycnni.org/article/S245... #MentalHealth💡 #FriedmanBrainInstitute
🧵 8/ Future Research: While our sample size was small and HEP methods need standardization, future studies could explore longitudinal interoceptive changes, combine interoceptive and autonomic measures, and test DBS effects across different targets. 🔬📈
February 10, 2025 at 5:42 PM
🧵 8/ Future Research: While our sample size was small and HEP methods need standardization, future studies could explore longitudinal interoceptive changes, combine interoceptive and autonomic measures, and test DBS effects across different targets. 🔬📈
🧵 7/ Implications: Interoception may play a role in the antidepressant effects of deep brain stimulation for TRD, strengthening the link between interoceptive processing and #depression. 🧠❤️
February 10, 2025 at 5:42 PM
🧵 7/ Implications: Interoception may play a role in the antidepressant effects of deep brain stimulation for TRD, strengthening the link between interoceptive processing and #depression. 🧠❤️
🧵 6/ HEP peaks and recovery: Monthly HEPs tracked with key neural transition points in the trajectory to wellness with DBS. www.nature.com/articles/s41... #DBS
We can begin to imagine how tracking patients' brain-body physiology can guide successful treatment of depression.
We can begin to imagine how tracking patients' brain-body physiology can guide successful treatment of depression.
Cingulate dynamics track depression recovery with deep brain stimulation - Nature
This study demonstrates how activity in the cingulate cortex tracks depression recovery, providing symptom relief using deep brain stimulation.
www.nature.com
February 10, 2025 at 5:42 PM
🧵 6/ HEP peaks and recovery: Monthly HEPs tracked with key neural transition points in the trajectory to wellness with DBS. www.nature.com/articles/s41... #DBS
We can begin to imagine how tracking patients' brain-body physiology can guide successful treatment of depression.
We can begin to imagine how tracking patients' brain-body physiology can guide successful treatment of depression.
🧵 5/Findings: Over 6 months, increased HEP amplitude correlates with faster antidepressant response (see figure below). Additionally, immediate application of DBS disrupts HEP amplitude; evidence that interoceptive circuits are modified.⚡📈
February 10, 2025 at 5:42 PM
🧵 5/Findings: Over 6 months, increased HEP amplitude correlates with faster antidepressant response (see figure below). Additionally, immediate application of DBS disrupts HEP amplitude; evidence that interoceptive circuits are modified.⚡📈
🧵 4/ What is HEP? Heartbeat-evoked potential (HEP) is an EEG marker that reflects how the brain processes the sensation of the heart. It helps us understand the neural basis of interoceptive awareness—how our brains perceive internal bodily sensations. 🧠♥️
February 10, 2025 at 5:42 PM
🧵 4/ What is HEP? Heartbeat-evoked potential (HEP) is an EEG marker that reflects how the brain processes the sensation of the heart. It helps us understand the neural basis of interoceptive awareness—how our brains perceive internal bodily sensations. 🧠♥️
🧵 3/ Exploring the heart-brain connection: We measured the heartbeat-evoked potential (HEP) in 8 patients with treatment-resistant depression, before and after 6 months of DBS treatment, to see how their brains process these interoceptive signals. #HEP
February 10, 2025 at 5:42 PM
🧵 3/ Exploring the heart-brain connection: We measured the heartbeat-evoked potential (HEP) in 8 patients with treatment-resistant depression, before and after 6 months of DBS treatment, to see how their brains process these interoceptive signals. #HEP
🧵 2/ Our inspiration: When severely depressed patients first experience SCC deep brain stimulation they report feeling lighter, calmer and warmer, and their heart rate increases— #interoception might be involved in #DBS antidepressant effects. 💓 pubmed.ncbi.nlm.nih.gov/26408865/
Mapping the "Depression Switch" During Intraoperative Testing of Subcallosal Cingulate Deep Brain Stimulation - PubMed
This analysis of transient behavior changes during intraoperative deep brain stimulation of the subcallosal cingulate and the subsequent identification of unique connectivity patterns may provide a bi...
pubmed.ncbi.nlm.nih.gov
February 10, 2025 at 5:42 PM
🧵 2/ Our inspiration: When severely depressed patients first experience SCC deep brain stimulation they report feeling lighter, calmer and warmer, and their heart rate increases— #interoception might be involved in #DBS antidepressant effects. 💓 pubmed.ncbi.nlm.nih.gov/26408865/