Khansa Saadallah
@el-khansa.bsky.social
Postdoctoral researcher in the Puissant Lab at Saint Louis Institute of Research. Passionate about blood cancer studies and biotechnology advancements.
Reposted by Khansa Saadallah
On cell extrusion in the #intestine!
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:
3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:
3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...
July 4, 2025 at 10:21 AM
On cell extrusion in the #intestine!
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:
3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:
3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...
Reposted by Khansa Saadallah
AML patient blasts exhibit polarization defects upon interaction with bone marrow stromal cells.
www.embopress.org/doi/full/10....
Work by Manuel Thery @manuelthery.bsky.social @institut-leucemie.bsky.social and co-workers.
www.embopress.org/doi/full/10....
Work by Manuel Thery @manuelthery.bsky.social @institut-leucemie.bsky.social and co-workers.
July 2, 2025 at 5:55 AM
AML patient blasts exhibit polarization defects upon interaction with bone marrow stromal cells.
www.embopress.org/doi/full/10....
Work by Manuel Thery @manuelthery.bsky.social @institut-leucemie.bsky.social and co-workers.
www.embopress.org/doi/full/10....
Work by Manuel Thery @manuelthery.bsky.social @institut-leucemie.bsky.social and co-workers.
Reposted by Khansa Saadallah
Our latest study about the polarization capacities of leukemic blasts was published today in #EMBOReports. www.embopress.org/doi/full/10.... @manuelthery.bsky.social @el-khansa.bsky.social LinaBenajiba @lobrylab.bsky.social
AML patient blasts exhibit polarization defects upon interaction with bone marrow stromal cells | EMBO reports
imageimageHSPCs polarize in contact with bone marrow stromal cells constituting their niche.
This study analyses the polarity of hematopoietic cells from AML patients using artificial
micro-niches and...
www.embopress.org
June 11, 2025 at 11:35 AM
Our latest study about the polarization capacities of leukemic blasts was published today in #EMBOReports. www.embopress.org/doi/full/10.... @manuelthery.bsky.social @el-khansa.bsky.social LinaBenajiba @lobrylab.bsky.social
Reposted by Khansa Saadallah
⭐️ Please Fwd. Are you in Paris on 16th May? See👇 poster of symposium on « Information processing in biological systems » @collegedefrance.bsky.social Fantastic line of speakers 🤩.
It is free, w/o registration, and it will be exciting.m!
Follows from my series of lectures at CdF last fall.
It is free, w/o registration, and it will be exciting.m!
Follows from my series of lectures at CdF last fall.
March 20, 2025 at 8:03 AM
⭐️ Please Fwd. Are you in Paris on 16th May? See👇 poster of symposium on « Information processing in biological systems » @collegedefrance.bsky.social Fantastic line of speakers 🤩.
It is free, w/o registration, and it will be exciting.m!
Follows from my series of lectures at CdF last fall.
It is free, w/o registration, and it will be exciting.m!
Follows from my series of lectures at CdF last fall.
Mitochondria with mtDNA mutations can be transferred from cancer cells to tumour infiltrating lymphocytes so they don't undergo mitophagy. @Ikeda
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature
Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.
www.nature.com
March 10, 2025 at 8:56 PM
Mitochondria with mtDNA mutations can be transferred from cancer cells to tumour infiltrating lymphocytes so they don't undergo mitophagy. @Ikeda
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Khansa Saadallah
Interested in how #stemcells sense their environment? Check out our work showing how #ECMatrix viscosity regulates #mechanosensing and #differentiation 🧪 Led by @theglasgowcemi.bsky.social @uofglasgow.bsky.social in collaboration with IBEC @natureportfolio.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
N-cadherin crosstalk with integrin weakens the molecular clutch in response to surface viscosity - Nature Communications
The crosstalk between cell-cell and cell-matrix adhesions regulates stem cell fate. Here, the authors reveal a critical role for matrix viscosity in controlling this crosstalk, which they explain via ...
www.nature.com
November 20, 2024 at 8:39 PM
Interested in how #stemcells sense their environment? Check out our work showing how #ECMatrix viscosity regulates #mechanosensing and #differentiation 🧪 Led by @theglasgowcemi.bsky.social @uofglasgow.bsky.social in collaboration with IBEC @natureportfolio.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...