Grateful to all participants and to insightful collaborators, including colleagues from Exeter's Transdisciplinary Psychedelics Research Group @leorroseman.bsky.social @profceliamorgan.bsky.social

⚖️ That said, some participants struggled with distressing or destabilizing experiences. We suggest that the ability to navigate and integrate psychedelic-induced epistemic shifts may depend on individuals’ capacity for uncertainty management ❗️❕

These findings further highlight awe’s potential role in facilitating lasting changes in perspective that support a more interconnected and holistic understanding of self and world.

Such shifts reflect the complex processes of meaning-making that psychedelics can catalyze, aligning with theories of transformative learning that emphasize perspective transformation through the integration of novel insights.

Thematic Network Analysis identified 3 clusters of epistemic shifts:
🟠Dissolution of societal and natural boundaries
🟣Expanded awareness and openness to complexity
🟢Greater compassion and acceptance of difference

Quant data showed awe—especially through vastness and connectedness—was significantly associated with increased self–other overlap.

These findings highlight awe’s potential to destabilize habitual self–world boundaries and open space for ontological and epistemic transformation.