We found a more strongly connected network in recurrent MDD when combining symptoms and brain characteristics. We also found that insomnia and somatic symptoms seem to be central to recurrent MDD, suggesting these symptoms could serve as possible clinical targets.

He used the REST MDD Dataset from Chaogan Yan and colleagues in China, and a multimodal network analysis:

We also found higher microglia count and region-specific phenotypes. More info in the preprint.

Using deformation-based morphometry, we found that morphine self-administration was related to volume changes in regions like cerebellum, basal ganglia and insula, among others.

For this we measured in vivo structural MRI before and after morphine self-administration using FR-1 in adolescent rats. Then, we did microscopy analysis of microglia cell count and phenotype using immunofluorescence.

More details in our preprint!