@edvardg.bsky.social
Reposted
Using 4570 longitudinal MRIs + 1684 Aβ PET scans from cognitively healthy older adults @jamesmroe.bsky.social find cortical thickness changed ≥7 years before PET-detectable Aβ. Those who later developed high Aβ already had thicker cortex & less thinning.
@LCBC_uio www.biorxiv.org/content/10.1...
@LCBC_uio www.biorxiv.org/content/10.1...
Cortical thickness changes precede high levels of amyloid by at least seven years
Alzheimer's disease (AD) is now defined based on its underlying brain pathology, with the presence of amyloid (Aβ) plaques at high enough levels sufficient to warrant a diagnosis in the absence of cog...
www.biorxiv.org
August 21, 2025 at 7:43 AM
Using 4570 longitudinal MRIs + 1684 Aβ PET scans from cognitively healthy older adults @jamesmroe.bsky.social find cortical thickness changed ≥7 years before PET-detectable Aβ. Those who later developed high Aβ already had thicker cortex & less thinning.
@LCBC_uio www.biorxiv.org/content/10.1...
@LCBC_uio www.biorxiv.org/content/10.1...
Reposted
Preprint: before age 60, between-people diffs in brain vols almost exclusively reflect stable diffs, while systematic diffs in rate-of-change in aging cause up to 40% of the variation to be due to change at 80 years. @edvardg.bsky.social 🧵https://www.biorxiv.org/content/10.1101/2025.05.26.655710v1
May 30, 2025 at 8:54 AM
Preprint: before age 60, between-people diffs in brain vols almost exclusively reflect stable diffs, while systematic diffs in rate-of-change in aging cause up to 40% of the variation to be due to change at 80 years. @edvardg.bsky.social 🧵https://www.biorxiv.org/content/10.1101/2025.05.26.655710v1