Eder Zavala
@ederzavala.bsky.social
Applied mathematician investigating endocrine rhythms • UKRI Future Leaders Fellow • Modelling stress, metabolism, fertility, sleep, inflammation, wearables • Immigrant 🇲🇽🇯🇵🇬🇧
Autumn colours in Birmingham.
November 4, 2025 at 7:59 AM
Autumn colours in Birmingham.
I have also been appointed Senior Lecturer in Mathematical Biomedicine at the Division of Diabetes, Endocrinology & Gastroenterology, in affiliation with the Centre for Biological Timing sites.manchester.ac.uk/bio-timing/ Stay tuned for PhD positions opening this week! (2/2)
October 14, 2025 at 10:58 AM
I have also been appointed Senior Lecturer in Mathematical Biomedicine at the Division of Diabetes, Endocrinology & Gastroenterology, in affiliation with the Centre for Biological Timing sites.manchester.ac.uk/bio-timing/ Stay tuned for PhD positions opening this week! (2/2)
Happy to announce that from 1st Dec I will join the University of Manchester @manchester.ac.uk as a UKRI Future Leaders Fellow @ukri.org, where my group will develop a new theoretical framework for Digital Endocrinology. I'm also looking forward to explore such a beautiful city! 🐝 (1/2)
October 14, 2025 at 10:58 AM
Happy to announce that from 1st Dec I will join the University of Manchester @manchester.ac.uk as a UKRI Future Leaders Fellow @ukri.org, where my group will develop a new theoretical framework for Digital Endocrinology. I'm also looking forward to explore such a beautiful city! 🐝 (1/2)
Just had a very exciting couple of days for the kickstart of UKRI Future Leaders Fellows cohort 9 in Glasgow. Truly impressed by the breadth, originality and quality of fellowship ideas 👌 A lot to live up to.
October 8, 2025 at 7:16 PM
Just had a very exciting couple of days for the kickstart of UKRI Future Leaders Fellows cohort 9 in Glasgow. Truly impressed by the breadth, originality and quality of fellowship ideas 👌 A lot to live up to.
Brief stop at Lancaster castle while attending the EPSRC early career forum on mathematical sciences.
September 18, 2025 at 9:20 AM
Brief stop at Lancaster castle while attending the EPSRC early career forum on mathematical sciences.
Here’s @belindombard.bsky.social explaining her poster at the 1st mathematical biology conference in Birmingham. Her work focuses on a data-driven mathematical model of the human HPA axis.
September 4, 2025 at 5:01 PM
Here’s @belindombard.bsky.social explaining her poster at the 1st mathematical biology conference in Birmingham. Her work focuses on a data-driven mathematical model of the human HPA axis.
Great time meeting colleagues at the @bsneuroendo.bsky.social meeting in Bradford! Had some really good discussions about mathematical modelling in neuroendocrinology.
September 4, 2025 at 4:58 PM
Great time meeting colleagues at the @bsneuroendo.bsky.social meeting in Bradford! Had some really good discussions about mathematical modelling in neuroendocrinology.
As the Birmingham lead, we will model the crosstalk interactions between the HPA axis, the renin-angiotensin system and the menstrual cycle, predicting their rhythmic behaviour as well as their dynamic responses to stimuli from clinical tests to environmental factors associated to disease. (2/3)
May 28, 2025 at 6:24 PM
As the Birmingham lead, we will model the crosstalk interactions between the HPA axis, the renin-angiotensin system and the menstrual cycle, predicting their rhythmic behaviour as well as their dynamic responses to stimuli from clinical tests to environmental factors associated to disease. (2/3)
Really exciting science from the chronobiology community in the UK clock club yesterday. Here’s Belinda with her poster on a data driven mathematical model of the HPA axis in humans @bioclocksuk.bsky.social
March 22, 2025 at 8:35 AM
Really exciting science from the chronobiology community in the UK clock club yesterday. Here’s Belinda with her poster on a data driven mathematical model of the HPA axis in humans @bioclocksuk.bsky.social
At Warwick university for the UK Clock Club 2025. Looking forward to hear about @bioclocksuk.bsky.social activity and showcase our work on HPA axis rhythms.
March 21, 2025 at 11:09 AM
At Warwick university for the UK Clock Club 2025. Looking forward to hear about @bioclocksuk.bsky.social activity and showcase our work on HPA axis rhythms.
That’s a wrap up for our workshop on modelling endocrine systems. Really grateful to the students from all over Mexico for their enthusiasm and dedication, and to CIMAT, CINVESTAV Mty and ITAM for contributing to a successful event. Already planning the 2nd edition!
February 14, 2025 at 1:32 AM
That’s a wrap up for our workshop on modelling endocrine systems. Really grateful to the students from all over Mexico for their enthusiasm and dedication, and to CIMAT, CINVESTAV Mty and ITAM for contributing to a successful event. Already planning the 2nd edition!
Day 3 of our workshop, this time talking about HPA axis rhythms and bifurcation analysis methods to understand the origin of rhythmic behaviour. So far getting great feedback from students 😀
February 13, 2025 at 3:15 AM
Day 3 of our workshop, this time talking about HPA axis rhythms and bifurcation analysis methods to understand the origin of rhythmic behaviour. So far getting great feedback from students 😀
Day 2 of our workshop on modelling endocrine systems, today focusing on metabolic models and uncertainty quantification methods.
February 11, 2025 at 7:21 PM
Day 2 of our workshop on modelling endocrine systems, today focusing on metabolic models and uncertainty quantification methods.
First day of our workshop on Mathematical Modelling of Endocrine Systems at the beautiful CIMAT centre for research in mathematics in Guanajuato, Mexico. Delighted to see so much enthusiasm from students attending from all over the country. modeladomsendocrino.eventos.cimat.mx/programa_mod...
February 11, 2025 at 12:53 AM
First day of our workshop on Mathematical Modelling of Endocrine Systems at the beautiful CIMAT centre for research in mathematics in Guanajuato, Mexico. Delighted to see so much enthusiasm from students attending from all over the country. modeladomsendocrino.eventos.cimat.mx/programa_mod...
On my way to Bath uni to talk about modelling of endocrine rhythms. Loving the views of the English countryside!
December 12, 2024 at 9:20 AM
On my way to Bath uni to talk about modelling of endocrine rhythms. Loving the views of the English countryside!
Looking forward to talk about mathematical analysis of endocrine rhythms to the biomaths group at @imperialcollegeldn.bsky.social #maths4health
December 2, 2024 at 11:19 AM
Looking forward to talk about mathematical analysis of endocrine rhythms to the biomaths group at @imperialcollegeldn.bsky.social #maths4health
For example, we can use maths to develop digital biomarkers that signal pathological hormonal rhythms, which combined with machine learning algorithms is key to speed up diagnosis and improve management of endocrine conditions. (4/4)
November 30, 2024 at 12:01 PM
For example, we can use maths to develop digital biomarkers that signal pathological hormonal rhythms, which combined with machine learning algorithms is key to speed up diagnosis and improve management of endocrine conditions. (4/4)
A key innovation was the U-RHYTHM wearable device, which automatically collects micro-volumes of interstitial fluid from underneath the skin, which has led to new discoveries and new ideas about endocrine function and human physiology. The potential is huge! 🤯 (3/4)
November 30, 2024 at 12:01 PM
A key innovation was the U-RHYTHM wearable device, which automatically collects micro-volumes of interstitial fluid from underneath the skin, which has led to new discoveries and new ideas about endocrine function and human physiology. The potential is huge! 🤯 (3/4)
An interdisciplinary collaboration spanning endocrinology, biochemistry and mathematics was key to help us understand how hormones such as cortisol fluctuate during the day and the (normal) differences observed within healthy people. (2/4)
November 30, 2024 at 12:01 PM
An interdisciplinary collaboration spanning endocrinology, biochemistry and mathematics was key to help us understand how hormones such as cortisol fluctuate during the day and the (normal) differences observed within healthy people. (2/4)
Interestingly, the model was able to predict 2 out of these 3 'dynamic phenotypes'. However, the response associated with the worst hormonal misalignment wasn't explainable by HPA axis regulation alone. This led us to hypothesise the influence of inflammatory mediators, yet to be determined! (3/3)
November 23, 2024 at 7:51 PM
Interestingly, the model was able to predict 2 out of these 3 'dynamic phenotypes'. However, the response associated with the worst hormonal misalignment wasn't explainable by HPA axis regulation alone. This led us to hypothesise the influence of inflammatory mediators, yet to be determined! (3/3)
The model focused on cortisol secretion and metabolism and was calibrated using high-frequency blood sampling data collected during and after heart surgery in adults. We used non-stationary statistical methods to identify 3 different types of dynamic response to surgery. (2/3)
November 23, 2024 at 7:51 PM
The model focused on cortisol secretion and metabolism and was calibrated using high-frequency blood sampling data collected during and after heart surgery in adults. We used non-stationary statistical methods to identify 3 different types of dynamic response to surgery. (2/3)
This "first generation" model was able to qualitatively explain previous experiments in rodents, such as the dynamic effects of estradiol implants in ovariectomized rats, of corticosteroid administration, and of acute stressors that slow down or ablate LH pulsatility. (2/3)
November 19, 2024 at 11:12 PM
This "first generation" model was able to qualitatively explain previous experiments in rodents, such as the dynamic effects of estradiol implants in ovariectomized rats, of corticosteroid administration, and of acute stressors that slow down or ablate LH pulsatility. (2/3)
The model also predicted the network is targeted by cytokines, which explained the dynamic dissociation between ACTH and corticosteroids observed during inflammatory stress. This was one of the first hints that modelling dynamic responses to stressors is context-dependent. (3/3)
November 16, 2024 at 4:45 PM
The model also predicted the network is targeted by cytokines, which explained the dynamic dissociation between ACTH and corticosteroids observed during inflammatory stress. This was one of the first hints that modelling dynamic responses to stressors is context-dependent. (3/3)
The model helped us make sense of data by inferring the existence of an intra-adrenal negative feedback loop. This feedback underpins dynamic responses to ACTH stimulation and plays a key role in the stress response. (2/3)
November 16, 2024 at 4:45 PM
The model helped us make sense of data by inferring the existence of an intra-adrenal negative feedback loop. This feedback underpins dynamic responses to ACTH stimulation and plays a key role in the stress response. (2/3)
Hello BlueSky 👋 Here’s to new discussions on mathematical neuroendocrinology, biomedicine and science in general. Say hi if you pop by!
November 12, 2024 at 9:03 PM
Hello BlueSky 👋 Here’s to new discussions on mathematical neuroendocrinology, biomedicine and science in general. Say hi if you pop by!