This is only maybe within the genres you listed
But it's a bop, so

In a Linux environment you can use Pipewire and Jack2 to set up patch bays for all your applications.
I run an RNN noise filter as a panel applet under Carla to filter Discord's output.
Have separate gain/compression stacks for media, since that way I can have one with no filtering for music

Barony! Absolutely fantastic for exactly that. Literally a 3D port of Nethack, but with enough interesting bits added on.
A little more mechanically heavy than that, but Cogmind is fantastic.
So is Caves of Qud, but that's even more of an RPG than just a dungeon delver.

They did just release the 1.0 update.

Abiotic Factor