David Weiss
@dweisslab.bsky.social
Professor of Infectious Diseases, Emory University School of Medicine. Director, Emory Antibiotic Resistance Center
We show how bacteria can adapt to B-lactam stress by increasing the copy number of "wimpy" beta-lactamases to overcome new drugs/B-lactamase inhibitors, without de novo evolution. This threatens the beta-lactam dominated antibiotic pipeline.
Congrats @jakechoby.bsky.social and team!
rdcu.be/euijW
Congrats @jakechoby.bsky.social and team!
rdcu.be/euijW
Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline
Nature Communications - Choby et al. show that dynamic increases in the copy number of preexisting β-lactamase genes in heteroresistance enables resistance of continua of cellular...
rdcu.be
July 2, 2025 at 6:15 PM
We show how bacteria can adapt to B-lactam stress by increasing the copy number of "wimpy" beta-lactamases to overcome new drugs/B-lactamase inhibitors, without de novo evolution. This threatens the beta-lactam dominated antibiotic pipeline.
Congrats @jakechoby.bsky.social and team!
rdcu.be/euijW
Congrats @jakechoby.bsky.social and team!
rdcu.be/euijW
@jakechoby.bsky.social is a rockstar - I encourage students/postdocs looking for an amazing mentor and excited to investigate a new frontier in antibiotic resistance to join Jake at UNC to study heteroresistance and defeat superbugs!
Congrats, Jake and team on this exciting paper.
Congrats, Jake and team on this exciting paper.
Excited to share the work with @dweisslab.bsky.social and great collaborators on how gene amplification generates dynamic heteroresistance to new beta-lactams, like cefiderocol. We hope drug developers will consider heteroresistance during antibiotic development rdcu.be/euijW
Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline
Nature Communications - Choby et al. show that dynamic increases in the copy number of preexisting β-lactamase genes in heteroresistance enables resistance of continua of cellular...
rdcu.be
July 2, 2025 at 6:08 PM
@jakechoby.bsky.social is a rockstar - I encourage students/postdocs looking for an amazing mentor and excited to investigate a new frontier in antibiotic resistance to join Jake at UNC to study heteroresistance and defeat superbugs!
Congrats, Jake and team on this exciting paper.
Congrats, Jake and team on this exciting paper.
Reposted by David Weiss
Alert! The abstract deadline for the Microbial Pathogenesis & Host Response meeting has been extended to July 7 meetings.cshl.edu/meetings.asp...
Microbial Pathogenesis & Host Response
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
meetings.cshl.edu
June 23, 2025 at 8:24 PM
Alert! The abstract deadline for the Microbial Pathogenesis & Host Response meeting has been extended to July 7 meetings.cshl.edu/meetings.asp...
Bactericidal antibiotics release bacterial DNA that activates TLR9, while static antibiotics do not. This can profoundly impact treatment outcome. Should clinicians consider this when choosing antibiotics to prescribe?
Amazing work by Julia Gross and collaboration with Iain Fraser!
rdcu.be/d1Phk
Amazing work by Julia Gross and collaboration with Iain Fraser!
rdcu.be/d1Phk
Bactericidal antibiotic treatment induces damaging inflammation via TLR9 sensing of bacterial DNA
Nature Communications - The immunologic differences induced by bactericidal versus bacteriostatic antibiotics remain unclear. Gross et al. show that, in contrast to static antibiotics, cidal...
rdcu.be
December 2, 2024 at 2:17 PM
Bactericidal antibiotics release bacterial DNA that activates TLR9, while static antibiotics do not. This can profoundly impact treatment outcome. Should clinicians consider this when choosing antibiotics to prescribe?
Amazing work by Julia Gross and collaboration with Iain Fraser!
rdcu.be/d1Phk
Amazing work by Julia Gross and collaboration with Iain Fraser!
rdcu.be/d1Phk