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dunodantis.bsky.social
duno 🧫🧪🍇🎄
@dunodantis.bsky.social
life is a constant refusal | UCI Chem PhD candidate @ Trader Lab 🍇 | Filipino chemical biologist messing around the immunoproteasome | kaphaynayan | he/siya 🏳️‍🌈🇵🇭
had my very first conference presentation as a grad student (well, as a human being really) at this year's Pacific Coast Protease conference at Borrego springs! :) happy to have spent time with experts and make connections with the community!

needless to say, the desert consumed me in its splendor
May 2, 2025 at 6:04 AM
Reposted by duno 🧫🧪🍇🎄
ByeTACs is finally out in J. Med Chem. Congrats team! Can't wait to see how else we can use this degradation technology. @codyloy.bsky.social

pubs.acs.org/doi/10.1021/...
ByeTAC: Bypassing E-Ligase-Targeting Chimeras for Direct Proteasome Degradation
The development of targeted protein degradation by recruiting a protein of interest to a ubiquitin ligase to facilitate its degradation has become a powerful therapeutic tool. The potential of this approach is limited to proteins that can be readily ubiquitinated and relies on having a ligand with the various E3 ligases. Here, we describe a new methodology for targeted protein degradation that directly recruits a protein of interest to the proteasome for degradation. We generated bifunctional molecules that incorporate a small molecule ligand into a subunit on the 26S proteasome that recruits the protein directly for degradation. ByeTAC degradation requires binding to Rpn-13, a nonessential ubiquitin receptor of the 26S proteasome, and the protein of interest and does not have to rely on the E ligase cascade for ubiquitination. The ByeTAC methodology demonstrates the application of directly recruiting a protein to the proteasome via interactions with Rpn-13 for degradation.
pubs.acs.org
April 21, 2025 at 7:13 PM
mayhaps....
Can it be done?!??!?!
March 21, 2025 at 6:51 AM
home for the holidays :) 🇵🇭
December 15, 2024 at 5:10 AM
i need a Zotero wrapped stat
December 4, 2024 at 7:28 PM
Reposted by duno 🧫🧪🍇🎄
This is huge.

The EFJ represents over 295,000 journalists in 44 countries 👇
www.thelondoneconomic.com/news/media/e...
European Federation of Journalists to stop posting content on X
The EFJ represents over 295,000 journalists in 44 countries.
www.thelondoneconomic.com
December 2, 2024 at 9:19 AM
agh finally another historical science biopic #joy #ivf
December 2, 2024 at 4:14 AM
i'm trying to get a chemical immunology project jumpstarted specifically on chemically harnessing antigen presentation machineries for T-cell activation.

immunology folks, can you help direct this baby immunologist to some really helpful fundamental resources 🥹 i'm currently lost in a rabbithole. 👀
November 25, 2024 at 3:27 AM
Reposted by duno 🧫🧪🍇🎄
Chemoproteomics starter pack, thanks mostly to @stephanhacker2.bsky.social's strong network go.bsky.app/JKJ1ZHt
November 18, 2024 at 1:18 AM
Reposted by duno 🧫🧪🍇🎄
“We can disagree and still love each other unless your disagreement is rooted in my oppression and denial of my humanity and right to exist”

- James Baldwin
November 18, 2024 at 5:15 AM
Reposted by duno 🧫🧪🍇🎄
Cool paper from Cravatt lab: Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes: www.cell.com/cell-chemica...
Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes
Many human proteins lack chemical probes and are even considered undruggable. Ogasawara et al. describe diversity-oriented synthesis-inspired photoreactive small molecules (photo-stereoprobes) and the...
www.cell.com
November 19, 2024 at 2:02 AM
love these starter packs so much :) can't wait for helpful and groundbreaking literature at the tips of my fingers
Chemoproteomics starter pack, thanks mostly to @stephanhacker2.bsky.social's strong network go.bsky.app/JKJ1ZHt
November 19, 2024 at 3:02 AM
:) corona del mar sunsets r gorgeous
November 17, 2024 at 8:48 PM
hello to the chemistry/chemical biology/larger scientific community here - special shout out to the girls, gays and the theys who do science!

here's a random picture of a Wicked (wink wink) fluorescent probe i synthesized this week.
November 16, 2024 at 8:15 AM