The PhD will supervised by both myself and @mirazrahman.bsky.social at @qmbci.bsky.social and @kingscollegelondon.bsky.social, and is an outstanding opportunity to gain expertise in structural biology, medicinal chemistry, and cancer biology, at the cutting edge of translational oncology.

A lovely lunch out to celebrate 5 years of the SoliLab, tinged with a little sadness as it coincides with one of the lab originals, Caroline, leaving us for bigger and better things! All the very best Dr Babisz and here’s to another 5 with this talented team!

Delighted to introduce Dr Caroline Babisz! Thank you @pseudoenzyme.bsky.social and Richard for being ace examiners 🔎. @qmbci.bsky.social

Lovely lunch with the lab today to celebrate Caroline submitting her thesis last week - the first of the SoliLab PhD students! Congratulations Caroline!!

The SoliLab celebrated Christmas a little early this year 🎄. A chilly, but lovely light trail, and a couple of 🍷 (for warmth, of course 😉).

Tamsin Wilcock is our newest recruit. Tamsin is working on a hugely challenging project but made major inroads since starting in June. KinETICS (Kinase Exact Tagging of In Cell Substrates) is our method of delivering an ATP analogue to live cells to find direct kinase substrates in situ - so cool!

Continuing the SoliLab introductions…Laura Knight joined the lab in 2023 as a MRC-DTP PhD student. Laura is working on the DNA damage response kinase, CHK2. She has identified 2 recurrent, cancer associated mutations which we hypothesise might rewire the DDR signalling pathways.

Now for Dr Irina Titkova. Irina is unravelling a novel mitotic pathway, which our data suggests is used by cancer cells to untangle tangled DNA to safely transit mitosis. This tumour-specific vulnerability is a potentially therapeutic actionable target which is an active area of research in our lab.

Next up, Caitlin Leo @caitlinsolilab.bsky.social - who has had to master both chemistry and biology in the first 2 years of her PhD! Caitlin has made a conformation-specific allosteric kinase inhibitor. I wish I could tell you more 🤐 but for now… exciting things are coming!

Let me introduce you to my brilliant team!
Caroline Babisz took a leap of faith on a new PI back in 2021 and has recently put down her pipettes to write up her thesis. Caroline has taken a multidisciplinary approach to understand the role of kinase activation loop modification on substrate selection

I’ve migrated here from the bird app so thought I’d (re)introduce myself and my group 👋🏻. I’m Tanya and I head the Kinase Signalling and Cancer group (aka The SoliLab) @ Barts Cancer Institute @qmbci.bsky.social Our research sits at the interface of fundamental kinase biology and cancer biology.