Good point.

Maybe it’s not about the averages but some courses were drastically shorter?

And 1 day off ICU LOS is £2000…

The 18 patients were diagnosed with triple-negative breast cancer that was not metastatic; no spread to other organs. There was no control group to assess efficacy of the treatment. With a small cohort, chance plays a big role. ~50% of patients would be cancer free at 3y.
4/4

The vaccine is well-tolerated and stimulates the immune system. Neoantigen-specific T cell responses were induced in 14/18 patients. At a median follow-up of 36 months, recurrence-free survival was 16/18 in the cohort of vaccinated patients.
3/4

Neoantigen, antigens present in tumour cells only, vaccines can induce or enhance specific antitumor immune responses with minimal risk of autoimmunity. 18 subjects (with remaining tumour after chemo) received 3x a DNA vaccine encoding on average 11 neoantigens per patient.
2/4

A challenge is how to afford those medicines mindful that the full benefits might take 10-20 years to translate into health savings, and obesity is associated with poverty?