@drrenefrank.bsky.social
Structural neuroscientist || Associate Professor || UKRI Future Leader Fellow using #cryoEM #teamtomo to explore inside mammalian brains
@AstburyCentre @UniversityLeeds
@AstburyCentre @UniversityLeeds
Reposted
Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software.
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
November 6, 2025 at 3:46 PM
Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software.
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
Reposted
We are recruiting 2 postdocs to work on bacterial motility using a combination of cryoEM, FLM and MD. An exciting collaboration with Kirsty Wan @micromotility.bsky.social Wolfram Moebius @wolframmoebius.bsky.social and Daniel Kattnig. Please see links in the thread below!
August 28, 2025 at 9:13 AM
We are recruiting 2 postdocs to work on bacterial motility using a combination of cryoEM, FLM and MD. An exciting collaboration with Kirsty Wan @micromotility.bsky.social Wolfram Moebius @wolframmoebius.bsky.social and Daniel Kattnig. Please see links in the thread below!
Reposted
If you’re attending #ACA2025 in Chicago, check out the talk by the amazing @alisiafadini.bsky.social. She’ll present new results on using experimental data (X-ray or #CryoEM) to guide AlphaFold even with very low resolution data! Session 2.1.3 at 11:10 on Sunday.
July 18, 2025 at 11:52 AM
If you’re attending #ACA2025 in Chicago, check out the talk by the amazing @alisiafadini.bsky.social. She’ll present new results on using experimental data (X-ray or #CryoEM) to guide AlphaFold even with very low resolution data! Session 2.1.3 at 11:10 on Sunday.
Reposted
Meanwhile, CryoEM continues to make strides: here, the swinging lever mechanism of the actinomysin power stroke is resolved in atomic- and time-resolved detail, via a myosin-5 mutant with slow hyrdolysis product release. Some very awesome single molecule biophysics! www.nature.com/articles/s41...
Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM - Nature
A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by my...
www.nature.com
April 16, 2025 at 2:24 AM
Meanwhile, CryoEM continues to make strides: here, the swinging lever mechanism of the actinomysin power stroke is resolved in atomic- and time-resolved detail, via a myosin-5 mutant with slow hyrdolysis product release. Some very awesome single molecule biophysics! www.nature.com/articles/s41...
Reposted
In-Situ High-Resolution Cryo-EM Reconstructions from CEMOVIS https://www.biorxiv.org/content/10.1101/2025.03.29.646093v1
March 31, 2025 at 8:46 AM
In-Situ High-Resolution Cryo-EM Reconstructions from CEMOVIS https://www.biorxiv.org/content/10.1101/2025.03.29.646093v1
Reposted
Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @cellcellpress.bsky.social www.cell.com/cell/fulltex.... What’s new?
March 5, 2025 at 4:02 PM
Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @cellcellpress.bsky.social www.cell.com/cell/fulltex.... What’s new?
Reposted
Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @margotriggi.bsky.social
February 28, 2025 at 2:04 PM
Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @margotriggi.bsky.social
Reposted
AlphaFold as a Prior: Experimental StructureDetermination Conditioned on a Pretrained Neural Network www.biorxiv.org/content/10.1101/2025.02.18.638828v1 #cryoem
February 22, 2025 at 8:10 AM
AlphaFold as a Prior: Experimental StructureDetermination Conditioned on a Pretrained Neural Network www.biorxiv.org/content/10.1101/2025.02.18.638828v1 #cryoem
Reposted
Great opportunity to join the Radford / Ranson labs and the world-renowned Astbury Centre as a Research Fellow in Structural Biology! Please see jobs.leeds.ac.uk/vacancy.aspx...
Job Opportunity at University of Leeds: Research Fellow in Structural Biology
Are you an ambitious researcher looking for your next challenge? Do you have an established background in structural studies of amyloid aggregates and want to help to develop new routes to combat amyl...
jobs.leeds.ac.uk
January 7, 2025 at 8:42 AM
Great opportunity to join the Radford / Ranson labs and the world-renowned Astbury Centre as a Research Fellow in Structural Biology! Please see jobs.leeds.ac.uk/vacancy.aspx...
Reposted
www.nature.com/articles/s41... Our study on the structural and functional characterization of anti-NMDAR autoimmune encephalitis is officially published. Key findings include: (1) Autoantibodies from three distinct patients exhibited unique binding patterns, with two binding sites per tetramer. 1/n)
Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis - Nature Structural & Molecular Biology
Anti-NMDA receptor encephalitis is the most common autoimmune encephalitis. Michalski et al. reveal epitope diversity, conformational changes and functional impacts of the autoantibodies using cryo-EM...
www.nature.com
December 13, 2024 at 4:31 PM
www.nature.com/articles/s41... Our study on the structural and functional characterization of anti-NMDAR autoimmune encephalitis is officially published. Key findings include: (1) Autoantibodies from three distinct patients exhibited unique binding patterns, with two binding sites per tetramer. 1/n)
Reposted
Excited to share our latest findings, now published @NatureNeuro www.nature.com/articles/s41...
We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties.
Threads will follow!
We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties.
Threads will follow!
December 2, 2024 at 10:02 AM
Excited to share our latest findings, now published @NatureNeuro www.nature.com/articles/s41...
We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties.
Threads will follow!
We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties.
Threads will follow!
Reposted
We have quite a range of PhD projects this year, covering cryo-EM methods, bacteriology/bioenergetics, and infection/antibiotics/vaccines. Would really appreciate if people can RT and share with their teams!
November 29, 2024 at 11:55 AM
We have quite a range of PhD projects this year, covering cryo-EM methods, bacteriology/bioenergetics, and infection/antibiotics/vaccines. Would really appreciate if people can RT and share with their teams!