Dr. Karl Nadolsky
@drkarlnadolsky.bsky.social
💥Endocrinologist (Hormone Physician)
💥Board certified endocrinology/diabetes/metabolism & obesity medicine
💥Cohost DocsWhoLift podcast
💥Endocrine Clinic at the Gym
💥Board certified endocrinology/diabetes/metabolism & obesity medicine
💥Cohost DocsWhoLift podcast
💥Endocrine Clinic at the Gym
Continuous Glucose Monitoring Frequency and Glycemic Control in Type 2 Diabetes
CGM may be unhelpful for healthy people without blood sugar dysregulation, but VERY helpful for type 2 #diabetes
jamanetwork.com/journals/jam...
CGM may be unhelpful for healthy people without blood sugar dysregulation, but VERY helpful for type 2 #diabetes
jamanetwork.com/journals/jam...
November 1, 2025 at 7:20 PM
Continuous Glucose Monitoring Frequency and Glycemic Control in Type 2 Diabetes
CGM may be unhelpful for healthy people without blood sugar dysregulation, but VERY helpful for type 2 #diabetes
jamanetwork.com/journals/jam...
CGM may be unhelpful for healthy people without blood sugar dysregulation, but VERY helpful for type 2 #diabetes
jamanetwork.com/journals/jam...
Be careful this #Halloween!
1️⃣ Yes, observational data still correlate diet soda with obesity and related disease.
Correlation does NOT equal causation
2️⃣ Interventional trials consistently show benefit of diet soda replacing sugary soda for #WeightLoss and #health - meaningful data
PMID: 34481971
1️⃣ Yes, observational data still correlate diet soda with obesity and related disease.
Correlation does NOT equal causation
2️⃣ Interventional trials consistently show benefit of diet soda replacing sugary soda for #WeightLoss and #health - meaningful data
PMID: 34481971
October 15, 2025 at 9:30 PM
Be careful this #Halloween!
1️⃣ Yes, observational data still correlate diet soda with obesity and related disease.
Correlation does NOT equal causation
2️⃣ Interventional trials consistently show benefit of diet soda replacing sugary soda for #WeightLoss and #health - meaningful data
PMID: 34481971
1️⃣ Yes, observational data still correlate diet soda with obesity and related disease.
Correlation does NOT equal causation
2️⃣ Interventional trials consistently show benefit of diet soda replacing sugary soda for #WeightLoss and #health - meaningful data
PMID: 34481971
I honestly don’t understand how the politicians can just fight about access to health insurance when it seems to me that the U.S. healthcare system’s dysfunction is rooted less in access to insurance and more in how the insurance system itself operates.
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October 9, 2025 at 4:33 PM
I honestly don’t understand how the politicians can just fight about access to health insurance when it seems to me that the U.S. healthcare system’s dysfunction is rooted less in access to insurance and more in how the insurance system itself operates.
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Another trial supporting artificial sweeteners over sugary consumption; after weight loss, randomized showing better maintenance with prolonged consumption of S&SEs in a healthy diet is a safe strategy for obesity management.
doi.org/10.1038/s422...
doi.org/10.1038/s422...
October 7, 2025 at 3:05 PM
Another trial supporting artificial sweeteners over sugary consumption; after weight loss, randomized showing better maintenance with prolonged consumption of S&SEs in a healthy diet is a safe strategy for obesity management.
doi.org/10.1038/s422...
doi.org/10.1038/s422...
Secondary Prevention of Atherosclerotic Cardiovascular Disease | review
August 22, 2025 at 10:11 PM
Secondary Prevention of Atherosclerotic Cardiovascular Disease | review
My simple way of explaining to patients of why exercise is so important metabolic health, including #diabetes, etc, is describing your muscle cells as sugar/fat burning factories.
Building and exercising your muscles is key for metabolic #health
#exercise #muscle #DocsWhoLift
Building and exercising your muscles is key for metabolic #health
#exercise #muscle #DocsWhoLift
August 7, 2025 at 12:56 PM
My simple way of explaining to patients of why exercise is so important metabolic health, including #diabetes, etc, is describing your muscle cells as sugar/fat burning factories.
Building and exercising your muscles is key for metabolic #health
#exercise #muscle #DocsWhoLift
Building and exercising your muscles is key for metabolic #health
#exercise #muscle #DocsWhoLift
July 29, 2025 at 7:53 PM
Can a ‘Cortisol Cocktail’ Help Relieve Stress?
Influencers say a concoction can boost energy and help you relax. Hormone experts (endocrinologists) will tell you that’s not true.
Real adrenal disease causing low cortisol is a very serious condition that requires therapy
Influencers say a concoction can boost energy and help you relax. Hormone experts (endocrinologists) will tell you that’s not true.
Real adrenal disease causing low cortisol is a very serious condition that requires therapy
July 21, 2025 at 12:57 PM
Can a ‘Cortisol Cocktail’ Help Relieve Stress?
Influencers say a concoction can boost energy and help you relax. Hormone experts (endocrinologists) will tell you that’s not true.
Real adrenal disease causing low cortisol is a very serious condition that requires therapy
Influencers say a concoction can boost energy and help you relax. Hormone experts (endocrinologists) will tell you that’s not true.
Real adrenal disease causing low cortisol is a very serious condition that requires therapy
July 1, 2025 at 11:27 AM
phase 2 trial showed 10-13% more #weightloss than diet/exercise alone (placebo) in obesity (no T2 #diabetes) and in those with T2D, 7-11% more weight loss than placebo along with a very good 1.5% reduction in hemoglobin A1c (blood sugar).
Presented at #ADA2025
@NEJM www.nejm.org/doi/full/10....
Presented at #ADA2025
@NEJM www.nejm.org/doi/full/10....
June 24, 2025 at 11:39 AM
phase 2 trial showed 10-13% more #weightloss than diet/exercise alone (placebo) in obesity (no T2 #diabetes) and in those with T2D, 7-11% more weight loss than placebo along with a very good 1.5% reduction in hemoglobin A1c (blood sugar).
Presented at #ADA2025
@NEJM www.nejm.org/doi/full/10....
Presented at #ADA2025
@NEJM www.nejm.org/doi/full/10....
Ozempic and blindness, again? On this week's #DocsWhoLift podcast, we welcome back one of our best buds & my former naval medicine roommate who went on to specialize in ophthalmology and vitreoretinal surgery, to discuss the most recent research into GLP-1ra therapy and eye disease.
June 23, 2025 at 3:41 PM
Ozempic and blindness, again? On this week's #DocsWhoLift podcast, we welcome back one of our best buds & my former naval medicine roommate who went on to specialize in ophthalmology and vitreoretinal surgery, to discuss the most recent research into GLP-1ra therapy and eye disease.
Influencers scaring people about normal cortisol fluctuation/physiology re #diet/#exercise based upon false premises while endocrinologists, neurosurgeons, urologists and oncology surgeons are working to care for the very serious real disease of pituitary/adrenal glands.
June 13, 2025 at 1:56 PM
Influencers scaring people about normal cortisol fluctuation/physiology re #diet/#exercise based upon false premises while endocrinologists, neurosurgeons, urologists and oncology surgeons are working to care for the very serious real disease of pituitary/adrenal glands.
Very high dose #ozempic in obesity with type 2 #diabetes phase 2 trial.
-modest additional sugar-lowering effect, with additional weight loss, at the expense of more side effects and treatment discontinuations.
diabetesjournals.org/care/article...
-modest additional sugar-lowering effect, with additional weight loss, at the expense of more side effects and treatment discontinuations.
diabetesjournals.org/care/article...
May 29, 2025 at 3:09 PM
Very high dose #ozempic in obesity with type 2 #diabetes phase 2 trial.
-modest additional sugar-lowering effect, with additional weight loss, at the expense of more side effects and treatment discontinuations.
diabetesjournals.org/care/article...
-modest additional sugar-lowering effect, with additional weight loss, at the expense of more side effects and treatment discontinuations.
diabetesjournals.org/care/article...
Review by @asmithryan, et al, provides a historical eval of #creatine in #women, potential applications across female life stages & recent research. They also consider the impact of hormonal changes on creatine metabolism and effectiveness as a dietary supplementation.
doi.org/10.1080/1550...
doi.org/10.1080/1550...
May 18, 2025 at 12:55 PM
Review by @asmithryan, et al, provides a historical eval of #creatine in #women, potential applications across female life stages & recent research. They also consider the impact of hormonal changes on creatine metabolism and effectiveness as a dietary supplementation.
doi.org/10.1080/1550...
doi.org/10.1080/1550...
Vitamin D, Falls and fracture presentation by longtime leading bone hormone researcher & expert Dr. Bess Dawson-Hughes at #AACE2025
💪🏽Too little, and too much, bad for fall risk. Optimal vit D (25-D) levels 20-40 ng/ml). Deficiency bad for balance, replenishment good.
💪🏽Too little, and too much, bad for fall risk. Optimal vit D (25-D) levels 20-40 ng/ml). Deficiency bad for balance, replenishment good.
May 16, 2025 at 1:59 PM
Vitamin D, Falls and fracture presentation by longtime leading bone hormone researcher & expert Dr. Bess Dawson-Hughes at #AACE2025
💪🏽Too little, and too much, bad for fall risk. Optimal vit D (25-D) levels 20-40 ng/ml). Deficiency bad for balance, replenishment good.
💪🏽Too little, and too much, bad for fall risk. Optimal vit D (25-D) levels 20-40 ng/ml). Deficiency bad for balance, replenishment good.
The real liver king & global leader in metabolic-associated fatty liver disease, Dr Cusi, illustrating why we (endocrinologists) need to collaborate with the community and primary care to address this risk. #aace2025
May 16, 2025 at 12:57 PM
The real liver king & global leader in metabolic-associated fatty liver disease, Dr Cusi, illustrating why we (endocrinologists) need to collaborate with the community and primary care to address this risk. #aace2025
LDL-c (now we use non-HDL-c & apoB), hsCRP, and Lp(a) among initially healthy European men and women was predictive of incident major adverse cardiovascular events (heart attacks, strokes, death from heart disease) during a 20-year period.
academic.oup.com/eurheartj/ad...
academic.oup.com/eurheartj/ad...
May 11, 2025 at 12:33 PM
LDL-c (now we use non-HDL-c & apoB), hsCRP, and Lp(a) among initially healthy European men and women was predictive of incident major adverse cardiovascular events (heart attacks, strokes, death from heart disease) during a 20-year period.
academic.oup.com/eurheartj/ad...
academic.oup.com/eurheartj/ad...
@rfk-junior.bsky.social suggests parents do their own research.
While that generally requires undergraduate degrees and then doctorate programs followed by extensive academic work, here are some basic steps on how to go about that. Good luck.
While that generally requires undergraduate degrees and then doctorate programs followed by extensive academic work, here are some basic steps on how to go about that. Good luck.
April 30, 2025 at 4:27 PM
@rfk-junior.bsky.social suggests parents do their own research.
While that generally requires undergraduate degrees and then doctorate programs followed by extensive academic work, here are some basic steps on how to go about that. Good luck.
While that generally requires undergraduate degrees and then doctorate programs followed by extensive academic work, here are some basic steps on how to go about that. Good luck.
The study examined safety reports of compounded glucagon-like peptide-1 receptor agonists (GLP-1 RAs like #semaglutide #tirzepatide) compared to FDA-approved products (#ozempic #wegovy #mounjaro #zepbound ).
April 29, 2025 at 4:59 PM
The study examined safety reports of compounded glucagon-like peptide-1 receptor agonists (GLP-1 RAs like #semaglutide #tirzepatide) compared to FDA-approved products (#ozempic #wegovy #mounjaro #zepbound ).
➡️ In patients with knee osteoarthritis and overweight or obesity, metformin, 2000 mg/d, for 6 months had a moderate and statistically significant effect on knee pain reduction compared with placebo.
JAMA. Published online April 24, 2025. doi:10.1001/jama.2025.3471
JAMA. Published online April 24, 2025. doi:10.1001/jama.2025.3471
April 25, 2025 at 4:15 PM
➡️ In patients with knee osteoarthritis and overweight or obesity, metformin, 2000 mg/d, for 6 months had a moderate and statistically significant effect on knee pain reduction compared with placebo.
JAMA. Published online April 24, 2025. doi:10.1001/jama.2025.3471
JAMA. Published online April 24, 2025. doi:10.1001/jama.2025.3471
Obesity complicated by prediabetes (intermediate stage between normal glycemia & type 2 #diabetes) is highly prevalent
#diet #exercise #weightloss
diabetesjournals.org/care/article...?
#diet #exercise #weightloss
diabetesjournals.org/care/article...?
April 24, 2025 at 5:42 PM
Obesity complicated by prediabetes (intermediate stage between normal glycemia & type 2 #diabetes) is highly prevalent
#diet #exercise #weightloss
diabetesjournals.org/care/article...?
#diet #exercise #weightloss
diabetesjournals.org/care/article...?