Jon Lippiat
@drjonlippiat.bsky.social
Academic and ion channel pharmacologist at the University of Leeds. I've finally made it over to this platform. Posting mainly about #ionchannels and maybe occasionally about wine, gin, holidays and silly things that I get up to.
KCNT1 gain-of-function variants cause severe, drug-resistant epilepsies, often with early onset and developmental regression. He we used a multi-model approach, combining computational screening, electrophysiology, and humanized KCNT1 Drosophila to identify existing drugs that inhibit KCNT1.
September 16, 2025 at 8:28 AM
KCNT1 gain-of-function variants cause severe, drug-resistant epilepsies, often with early onset and developmental regression. He we used a multi-model approach, combining computational screening, electrophysiology, and humanized KCNT1 Drosophila to identify existing drugs that inhibit KCNT1.