David Griffin 🦠🧫💉
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drdavidwjg.bsky.social
David Griffin 🦠🧫💉
@drdavidwjg.bsky.social
👨🏼‍🎓BSc, MBBS, MPH, FRACP👨🏼‍⚕️
Infectious Diseases Doc, PhD Candidate. Interests: #HIV, #BBV, #TxID, #IPC, #Vaccines

#IDSky #HIVSky

Auch auf Deutsch verfügbar.

🇦🇺🇩🇪🏳️‍🌈 he/him
Pleased to share results of our discrete choice experiment of the influence of HIV on organ procurement and allocation in Australia #HIVAIDS2025

#healthequity #IDsky #HIVsky #TxIDsky #PhD
September 15, 2025 at 5:03 AM
Important #latebreaker study at #CROI2025 SCORPIO-PEP phase III RCT showed ensitrelvir (Day 1: 375mg, Day 2-5: 125mg) reduced PCR positive, symptomatic #COVID19 in HHC if started w/in 72 hrs of index case symptomatic C19 by 67%. Including in those with high risk progression. Need ICH and RACF data!
March 12, 2025 at 7:31 PM
Ten Americas: a systematic analysis of life expectancy disparities in the USA - @thelancet.bsky.social

Somber update on the 8 Americas study; highlights growing inequities in life expectancy, impact of structural racism and disproportionate impact of #COVID19

www.thelancet.com/journals/lan...
November 23, 2024 at 11:46 PM
Dr Eloise Williams gave an important update confirmatory testing for #HIV in Australia.

#MicroSky #HIVsky #IDsky
#HIVinFocus

- Use of accredited NAAT in diagnostics (cf monitoring) on separate sample to initial serology
- p24 Ag immunoassay (no longer available)
- (traditional) western blot
November 23, 2024 at 11:21 PM
Vikas Parwani from HIV/AIDS Legal Center shares a brief insight into immigration to Aus for #PWH.

Immigration exempt from discrimination laws that protect #PWH.

#HIV can be barrier due to perceived cost, but opportunities for ‘health waiver’ exist. HIV not the only barrier #PWH face. #HIVinFocus
November 23, 2024 at 2:03 AM
A/Prof. Mina John from Royal Perth Hospital, presents Western Australian data on implementation LAI ART in hard to reach populations, mirroring #UCSF data; improved retention in care and virological suppression.

Multiple other benefits.

#HIVsky #IDsky
November 23, 2024 at 12:36 AM
3/ #HIVinFocus

International guidelines recommend implementing the #Reprievestudy findings with different thresholds of #CVD risk statin therapy.

Australian guidance most closely aligns with the EACS recommendation.
November 22, 2024 at 11:34 PM
2/ Australian CVD risk calculators typically assign a lower risk to #PWH than AHA/ACC score.

International guidelines recommend implementing this evidence differently.
November 22, 2024 at 11:34 PM
A/Prof Janine Trevillyan from #AustinHealth describes the challenges of applying the #REPRIEVEstudy in Australia; we don’t have pitavastatin and use different risk calculators. #IDsky #HIVsky

Atorva- and rosuvastatin reduce surrogates of CVD risk, though choosing ideal biomarker can be challenging.
November 22, 2024 at 11:34 PM
6/ #REPRIEVEstudy also highlighted that #CVD risk calculators tend to overestimate CVD risk in developing countries, but underestimate risk in women.
November 22, 2024 at 10:47 PM
5/ #REPRIEVEstudy showed that statins were safe (pitavastatin was chosen because it doesn’t interact with PIs), with a non-sig trend towards incident #diabetes, though glycaemic control was curiously unchanged.
November 22, 2024 at 10:47 PM
4/ #REPRIEVEstudy demonstrated definitively that statins reduce CVD risk in people with #HIV 35% with low to moderate #ASCVD risk at baseline.
November 22, 2024 at 10:47 PM
3/ mechanistically statins reduce CVD risk through several mechanisms; LDL lowering, plaque stabilization, dampening inflammation. Interestingly #REPRIEVEstudy proteomic analysis suggested PCOLCE may be important in pitavastatin impact on collagen deposition.
November 22, 2024 at 10:47 PM
2/ importance of identifying and addressing lifestyle factors, social and psychological determinants of health to reduce #CVD risk
November 22, 2024 at 10:47 PM
Day 2 #HIVinFocus

Prof. Currier from #UCLA offering insights into CVD risk in #PWH.

First, association between clonal hematopoiesis and #CVD risk in #HIV demonstrated in several cohorts.
November 22, 2024 at 10:47 PM
#HIVsky #IDsky

Remember cystatin C as an alternative to creatinine for estimating renal function in people with HIV with elevated creatinine on INSTI and/or cobicistat.

- nephrologist, Dr Nichita GAVRILESCU #HIVinFocus
November 22, 2024 at 8:05 AM
Great talk by Endocrinologist A/Prof. Priya Sumithran at #HIVinFocus symposium.

- weight loss is an uphill battle
- pharmacological management available with additional health benefits
- questions remain about functional impact of muscle loss
- meds only work while taking them!
#IDsky #HIVsky
November 22, 2024 at 1:01 AM
Prof. Jenny Hoy, summarises ART and weight gain at #HIVinFocus symposium at Alfred Health.

#HIVSky
November 22, 2024 at 12:26 AM
One can try to slice the data however they will, but the ⬇️ in morbidity, mortality and incidence of several infectious diseases due to #vaccination is irrefutable.

We’ve seen time and again, the consequences of disruption of immunisation programs (e.g. MMR in Samoa), and ⬇️ in herd immunity #IDsky
November 18, 2024 at 11:28 PM
Super pleased to receive an award for our research on barriers to #SOT for people with #HIV among clinicians and consumers in Australia.

#IDSky #HIVSky #HealthEquity
November 15, 2024 at 2:34 AM