Aria Vaishnavi, PhD
@drariav.bsky.social
Assistant professor at MD Anderson Cancer Center and CPRIT scholar. Cancer biologist.
That’s a great question! We haven’t really looked yet but could definitely explore that!
May 9, 2025 at 10:16 PM
That’s a great question! We haven’t really looked yet but could definitely explore that!
Collectively, this work provides evidence for an important role for ERBB family signaling in the genesis and maintenance of BRAFV600E-driven lung cancers, and the potential for future therapeutic improvement by rational combination targeting of these pathways.
May 9, 2025 at 8:19 PM
Collectively, this work provides evidence for an important role for ERBB family signaling in the genesis and maintenance of BRAFV600E-driven lung cancers, and the potential for future therapeutic improvement by rational combination targeting of these pathways.
Here, using genetic and patient-derived mouse models, we reveal that activation of BRAFV600E oncoprotein drives transcriptional upregulation of ERBB family ligands in the AT2 cells of the lung. This ERBB autocrine loop serves to support the initiation and maintenance of BRAFV600E tumors in the lung.
May 9, 2025 at 8:18 PM
Here, using genetic and patient-derived mouse models, we reveal that activation of BRAFV600E oncoprotein drives transcriptional upregulation of ERBB family ligands in the AT2 cells of the lung. This ERBB autocrine loop serves to support the initiation and maintenance of BRAFV600E tumors in the lung.
You hit the nail on the head with this post!
March 5, 2025 at 4:03 AM
You hit the nail on the head with this post!
Yes! I have a couple I can email you— one is from scratch and one is “pretty” defined but both work great for lung adenos
December 27, 2024 at 6:57 AM
Yes! I have a couple I can email you— one is from scratch and one is “pretty” defined but both work great for lung adenos