Anne Carpenter
@drannecarpenter.bsky.social
Dedicated to drug discovery, enthralled by science. 5 kids. She. SAB Recursion. Founder SyzOnc. Lab at Broad Institute. Opinions my own.
Chocolate chips are enormously helpful in this regard.
October 23, 2025 at 9:25 AM
Chocolate chips are enormously helpful in this regard.
The McLean team deserves all the credit for noticing the mitochondria by eye! It was a slog quantifying it, but the major insight was seeing it by eye, and the major work here was cataloging all the patients and preparing their cell samples. Very glad to be included in this important project!!
October 13, 2025 at 10:42 AM
The McLean team deserves all the credit for noticing the mitochondria by eye! It was a slog quantifying it, but the major insight was seeing it by eye, and the major work here was cataloging all the patients and preparing their cell samples. Very glad to be included in this important project!!
It just goes to show that the more we think we know, the more there is there is to learn!
Here is the paper mentioned
pubmed.ncbi.nlm.nih.gov/38405915/
Here is the paper mentioned
pubmed.ncbi.nlm.nih.gov/38405915/
Most axonal mitochondria in cortical pyramidal neurons lack mitochondrial DNA and consume ATP - PubMed
In neurons of the mammalian central nervous system (CNS), axonal mitochondria are thought to be indispensable for supplying ATP during energy-consuming processes such as neurotransmitter release. Here...
pubmed.ncbi.nlm.nih.gov
October 12, 2025 at 6:49 PM
It just goes to show that the more we think we know, the more there is there is to learn!
Here is the paper mentioned
pubmed.ncbi.nlm.nih.gov/38405915/
Here is the paper mentioned
pubmed.ncbi.nlm.nih.gov/38405915/
I personally have no idea, because it’s outside my expertise, but I’m guessing the researchers that we cite in the discussion who discovered that would have some speculation, or maybe even solid theory or evidence!
October 12, 2025 at 6:46 PM
I personally have no idea, because it’s outside my expertise, but I’m guessing the researchers that we cite in the discussion who discovered that would have some speculation, or maybe even solid theory or evidence!
Neat! I don’t know if there’s a connection.
October 12, 2025 at 11:23 AM
Neat! I don’t know if there’s a connection.
Interesting connection!
October 11, 2025 at 12:57 PM
Interesting connection!
Mostly no! Which i am excited about, because existing treatments are not great for most patients. So we’d love to have medicines with a very different mechanism than the existing ones.
October 11, 2025 at 12:56 PM
Mostly no! Which i am excited about, because existing treatments are not great for most patients. So we’d love to have medicines with a very different mechanism than the existing ones.