dr-jayne-ellis.bsky.social
@dr-jayne-ellis.bsky.social
AHD clinical researcher, Infectious Diseases Institute, Kampala, Uganda
Wellcome Global Health Research Clinical PhD Fellow, LSHTM
Infectious Disease/Micro trainee, UCLH
93% achieved HIV virological suppression by 32-weeks post
1HP, and there were no cases of cryptococcal relapse.
July 16, 2025 at 1:24 PM
Day-14 dolutegravir C24h geometric mean (trough level)
was 0.61 (95%CI 0.32-1.16) mg/L, 9-fold higher than the
dolutegravir IC90 of 0.064 mg/L
July 16, 2025 at 1:24 PM
Despite expected reductions in exposure, once-daily 50mg
dolutegravir and 800mg fluconazole dosing may be safe and
effective during 1HP amongst adults with advanced HIV
disease receiving treatment for cryptococcal meningitis.
July 16, 2025 at 1:16 PM