Dan Angelov
@dr-chromatin.bsky.social
Physician-Scientist.
Haematologist - Lymphoma.
Functional Genomics in Blood Cancers.
Chromatin Biology.
Haematologist - Lymphoma.
Functional Genomics in Blood Cancers.
Chromatin Biology.
Absolutely delighted to share our preprint, using functional genomics to uncover a novel dependency in lymphoma that can overcome resistance to targeted therapy. Grateful to co-first author @jamesnolan.bsky.social and co-senior authors @conwayer1.bsky.social and @adrianbracken.bsky.social see👇
🧵1/Exciting news in cancer epigenetics! Our latest research, "AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma", is now available on www.biorxiv.org/content/10.1.... Here's a thread summarizing our findings!👇
#CancerResearch #Epigenetics #Chromatin #Lymphoma
#CancerResearch #Epigenetics #Chromatin #Lymphoma
AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma
The catalytic subunit of Polycomb Repressive Complex 2 (PRC2), EZH2, is recurrently mutated in 25% of diffuse large B-cell lymphomas (DLBCL), causing increased H3K27me3 and decreased H3K27me2 levels. ...
www.biorxiv.org
October 17, 2025 at 2:07 PM
Absolutely delighted to share our preprint, using functional genomics to uncover a novel dependency in lymphoma that can overcome resistance to targeted therapy. Grateful to co-first author @jamesnolan.bsky.social and co-senior authors @conwayer1.bsky.social and @adrianbracken.bsky.social see👇
Reposted by Dan Angelov
Please see 🧵by @evhealy.bsky.social about our new paper exploring the role of PRC1 and PRC2 in non-dividing cells 👇
🧵 1/ We’re excited to share that our new paper with @adrianbracken.bsky.social lab is out 🎉 In this study (which began over 10 years ago!), we explore the biology of PRC2 and PRC1 in non-dividing cells. We also explore the effects of PRC2 inhibitor drugs on these cells. Here’s what we found👇
January 14, 2025 at 11:03 PM
Please see 🧵by @evhealy.bsky.social about our new paper exploring the role of PRC1 and PRC2 in non-dividing cells 👇
Reposted by Dan Angelov
Thrilled to share a wonderful collaboration with Scott Armstrong, Florian Perner & Shellaina Gordon - exciting times ahead!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia
Understanding the molecular pathogenesis of MLL fusion oncoprotein (MLL-FP) leukaemia has spawned epigenetic therapies that have improved clinical outcomes in this often-incurable disease. Using genet...
www.biorxiv.org
December 13, 2024 at 9:07 PM
Thrilled to share a wonderful collaboration with Scott Armstrong, Florian Perner & Shellaina Gordon - exciting times ahead!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Dan Angelov
Our final webinar before Christmas 🎅 is coming up!
We will be joined by Luciano Di Croce for his webinar on 'Dissecting Dynamics of Chromatin Function in Cell Differentiation and Cancer'.
Register here: us06web.zoom.us/webinar/regi...
@activemotifusa.bsky.social
We will be joined by Luciano Di Croce for his webinar on 'Dissecting Dynamics of Chromatin Function in Cell Differentiation and Cancer'.
Register here: us06web.zoom.us/webinar/regi...
@activemotifusa.bsky.social
December 4, 2024 at 10:50 AM
Our final webinar before Christmas 🎅 is coming up!
We will be joined by Luciano Di Croce for his webinar on 'Dissecting Dynamics of Chromatin Function in Cell Differentiation and Cancer'.
Register here: us06web.zoom.us/webinar/regi...
@activemotifusa.bsky.social
We will be joined by Luciano Di Croce for his webinar on 'Dissecting Dynamics of Chromatin Function in Cell Differentiation and Cancer'.
Register here: us06web.zoom.us/webinar/regi...
@activemotifusa.bsky.social
Reposted by Dan Angelov
Looking forward to sharing collaborative work by myself and @dr-chromatin.bsky.social from the labs of @adrianbracken.bsky.social and @conwayer1.bsky.social at #ASH24 in San Diego this week. #hemesky #lymsm please feel free to stop by and share your thoughts.
December 5, 2024 at 7:04 PM
Looking forward to sharing collaborative work by myself and @dr-chromatin.bsky.social from the labs of @adrianbracken.bsky.social and @conwayer1.bsky.social at #ASH24 in San Diego this week. #hemesky #lymsm please feel free to stop by and share your thoughts.
Reposted by Dan Angelov
The Groth lab @grothlab.bsky.social has also made the jump from X to Bluesky🤩! Please follow us for all things related to chromatin replication, epigenetic memory and (epi)genome stability in the context of mitotic cell division! We'll start on joining some relevant starter packs!
November 25, 2024 at 12:02 PM
The Groth lab @grothlab.bsky.social has also made the jump from X to Bluesky🤩! Please follow us for all things related to chromatin replication, epigenetic memory and (epi)genome stability in the context of mitotic cell division! We'll start on joining some relevant starter packs!
This is amazing. Menin inhibitors FDA approved! Such a quick turnaround from drug discovery, to molecular mechanisms and on to clinical trials showing efficacy and favourable safety profile.
A huge win for the field of epigenetic targeted drugs! Kudos to all involved.
www.fda.gov/drugs/resour...
A huge win for the field of epigenetic targeted drugs! Kudos to all involved.
www.fda.gov/drugs/resour...
FDA approves revumenib for relapsed or refractory acute leukemia
On November 15, 2024, the FDA approved revumenib (Revuforj, Syndax Pharmaceuticals, Inc.) for relapsed or refractory acute leukemia with a KMT2A translocation.
www.fda.gov
November 24, 2024 at 7:33 PM
This is amazing. Menin inhibitors FDA approved! Such a quick turnaround from drug discovery, to molecular mechanisms and on to clinical trials showing efficacy and favourable safety profile.
A huge win for the field of epigenetic targeted drugs! Kudos to all involved.
www.fda.gov/drugs/resour...
A huge win for the field of epigenetic targeted drugs! Kudos to all involved.
www.fda.gov/drugs/resour...
Reposted by Dan Angelov
Exciting weekend read from G Cavailli's lab, on how histone acetylation turnover shapes 3D genome folding and transcriptional memory
+ Deepest micro-C ever in mESCs 😲 + Protocol updates for reducing coverage biases of micro-C 🤔
www.biorxiv.org/content/10.1...
+ Deepest micro-C ever in mESCs 😲 + Protocol updates for reducing coverage biases of micro-C 🤔
www.biorxiv.org/content/10.1...
Transient histone deacetylase inhibition induces cellular memory of gene expression and three-dimensional genome folding
Epigenetic memory enables the stable propagation of gene expression patterns in response to transient developmental and environmental stimuli. Although three-dimensional (3D) organisation is emerging ...
www.biorxiv.org
November 23, 2024 at 10:29 PM
Exciting weekend read from G Cavailli's lab, on how histone acetylation turnover shapes 3D genome folding and transcriptional memory
+ Deepest micro-C ever in mESCs 😲 + Protocol updates for reducing coverage biases of micro-C 🤔
www.biorxiv.org/content/10.1...
+ Deepest micro-C ever in mESCs 😲 + Protocol updates for reducing coverage biases of micro-C 🤔
www.biorxiv.org/content/10.1...
Reposted by Dan Angelov
Unfortunately, we have to postpone tomorrow’s webinar with Emma Farley. We will reschedule as soon as we can!
Nice to see all you chromatin & epigenetics aficionados here! As we build our network back up please repost details for our upcoming webinar this Friday!
We are delighted to welcome Emma Farley for her webinar 'Dependency Grammar of Developmental Enhancers' on November 22nd. Registration below 👇
We are delighted to welcome Emma Farley for her webinar 'Dependency Grammar of Developmental Enhancers' on November 22nd. Registration below 👇
November 21, 2024 at 5:09 PM
Unfortunately, we have to postpone tomorrow’s webinar with Emma Farley. We will reschedule as soon as we can!
Reposted by Dan Angelov
How does PRC1 counteract transcription?
See this preview from @adrianbracken.bsky.social and I on an exciting new study from @robklose.bsky.social lab where they show ncPRC1 blocks the early stages of transcription.
www.sciencedirect.com/science/arti...
@conwayer1.bsky.social for title inspo!
See this preview from @adrianbracken.bsky.social and I on an exciting new study from @robklose.bsky.social lab where they show ncPRC1 blocks the early stages of transcription.
www.sciencedirect.com/science/arti...
@conwayer1.bsky.social for title inspo!
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
November 20, 2024 at 11:19 PM
How does PRC1 counteract transcription?
See this preview from @adrianbracken.bsky.social and I on an exciting new study from @robklose.bsky.social lab where they show ncPRC1 blocks the early stages of transcription.
www.sciencedirect.com/science/arti...
@conwayer1.bsky.social for title inspo!
See this preview from @adrianbracken.bsky.social and I on an exciting new study from @robklose.bsky.social lab where they show ncPRC1 blocks the early stages of transcription.
www.sciencedirect.com/science/arti...
@conwayer1.bsky.social for title inspo!
Reposted by Dan Angelov
I couldn't find a starter pack for the hematology community so I created one:
go.bsky.app/8K9pgxU
go.bsky.app/8K9pgxU
November 11, 2024 at 1:16 AM
I couldn't find a starter pack for the hematology community so I created one:
go.bsky.app/8K9pgxU
go.bsky.app/8K9pgxU
Absolutely brilliant film making from Éanna Mac Cana, a fascinating tale of Denis Burkitt, an Irish surgeon who discovered and characterised Burkitt lymphoma, and Éanna’s own experience with the disease #Scienceweek #AICRI
November 16, 2024 at 11:33 PM
Absolutely brilliant film making from Éanna Mac Cana, a fascinating tale of Denis Burkitt, an Irish surgeon who discovered and characterised Burkitt lymphoma, and Éanna’s own experience with the disease #Scienceweek #AICRI
Just moved from Twitter. Hoping to re-engage with all the lovely scientists I used to see on my feed before it was corrupted by nonsense!
November 16, 2024 at 11:33 PM
Just moved from Twitter. Hoping to re-engage with all the lovely scientists I used to see on my feed before it was corrupted by nonsense!