Dow Lab
@dowlab.bsky.social
Desperately trying to understand the cancer genome
KRAS | WNT | CRISPR | Base editing
Sometimes building guitars
www.dowlab.org
KRAS | WNT | CRISPR | Base editing
Sometimes building guitars
www.dowlab.org
Pinned
Dow Lab
@dowlab.bsky.social
· Mar 12
A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression
Hyperactive WNT signaling is a potent cancer driver, but clinical translation of WNT inhibitors has been hampered on-target toxicities. WNT signaling can be constrained through inhibition of the PARP ...
www.biorxiv.org
New preprint time!!
This one has been brewing in the lab for ~8 years describes a strategy for tumor selective WNT suppression. It was led by an amazing (then) grad student, Jill Zimmerman, with help from a host of lab members and collaborators along the way.
www.biorxiv.org/content/10.1...
This one has been brewing in the lab for ~8 years describes a strategy for tumor selective WNT suppression. It was led by an amazing (then) grad student, Jill Zimmerman, with help from a host of lab members and collaborators along the way.
www.biorxiv.org/content/10.1...
No time for a #bluetorial today, but happy to share a new preprint from the lab. In this paper we used gene saturation and cancer-mutation-focused base editing screens to unveil genetic drivers of resistance to multiple KRAS inhibitors. www.biorxiv.org/content/10.1...
Genetic mechanisms of resistance to targeted KRAS inhibition
KRAS mutations are among the most prevalent oncogenic drivers in non-small cell lung cancer (NSCLC), yet the mechanisms of therapeutic resistance to KRAS inhibitors in these cancers remains poorly und...
www.biorxiv.org
August 4, 2025 at 8:15 PM
No time for a #bluetorial today, but happy to share a new preprint from the lab. In this paper we used gene saturation and cancer-mutation-focused base editing screens to unveil genetic drivers of resistance to multiple KRAS inhibitors. www.biorxiv.org/content/10.1...
I promise this is a science account and we have multiple papers brewing, but for now… latest guitar is finished!! This one is my own design and built entirely from scratch. Took ~6 months as my real job kept getting in the way…
June 17, 2025 at 9:31 PM
I promise this is a science account and we have multiple papers brewing, but for now… latest guitar is finished!! This one is my own design and built entirely from scratch. Took ~6 months as my real job kept getting in the way…
New preprint time!!
This one has been brewing in the lab for ~8 years describes a strategy for tumor selective WNT suppression. It was led by an amazing (then) grad student, Jill Zimmerman, with help from a host of lab members and collaborators along the way.
www.biorxiv.org/content/10.1...
This one has been brewing in the lab for ~8 years describes a strategy for tumor selective WNT suppression. It was led by an amazing (then) grad student, Jill Zimmerman, with help from a host of lab members and collaborators along the way.
www.biorxiv.org/content/10.1...
A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression
Hyperactive WNT signaling is a potent cancer driver, but clinical translation of WNT inhibitors has been hampered on-target toxicities. WNT signaling can be constrained through inhibition of the PARP ...
www.biorxiv.org
March 12, 2025 at 4:08 PM
New preprint time!!
This one has been brewing in the lab for ~8 years describes a strategy for tumor selective WNT suppression. It was led by an amazing (then) grad student, Jill Zimmerman, with help from a host of lab members and collaborators along the way.
www.biorxiv.org/content/10.1...
This one has been brewing in the lab for ~8 years describes a strategy for tumor selective WNT suppression. It was led by an amazing (then) grad student, Jill Zimmerman, with help from a host of lab members and collaborators along the way.
www.biorxiv.org/content/10.1...
On the old bird app, I promised to post updates on the latest guitar build… I failed, but will make up for lost time here. This one is a custom design, larger body (modified grand symphony), koa top back and sides, ebony binding and fretboard, and a bunch of abalone (for the Hawaiian island vibe).
March 9, 2025 at 12:14 PM
On the old bird app, I promised to post updates on the latest guitar build… I failed, but will make up for lost time here. This one is a custom design, larger body (modified grand symphony), koa top back and sides, ebony binding and fretboard, and a bunch of abalone (for the Hawaiian island vibe).
Hello, bsky! First post is fun one - Today I moved to Professor with tenure at @weillcornell.bsky.social! Huge thanks to everyone who has contributed to our efforts over the last decade. It takes a village! Looking forward to more science and guitar building posts on #newoldtwitter.
a man wearing glasses and a jacket is standing in a doorway and says `` oh , hello , professor . ''
ALT: a man wearing glasses and a jacket is standing in a doorway and says `` oh , hello , professor . ''
media.tenor.com
March 8, 2025 at 12:23 AM
Hello, bsky! First post is fun one - Today I moved to Professor with tenure at @weillcornell.bsky.social! Huge thanks to everyone who has contributed to our efforts over the last decade. It takes a village! Looking forward to more science and guitar building posts on #newoldtwitter.