Donner Lab
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donnerlab.bsky.social
Donner Lab
@donnerlab.bsky.social
The goal of our research is to understand how brain states shape decision-making, and how this process goes awry in certain neurological & psychiatric disorders
| tobiasdonner.net | University Medical Center Hamburg-Eppendorf, Germany
It fits the behavioral data better than a range of alternatives, and reproduces a number of behavioral and neural signatures, including the concurrently measured dynamics of the encoding of contrast samples in visual cortex.
November 3, 2025 at 9:12 PM
Our model combines sensory adaptation, leaky accumulation with feed-forward inhibition, and an asymmetric readout of the DVs in confidence formation.
November 3, 2025 at 9:12 PM
We next used single-trial regression to predict confidence from the winning and losing DVs, controlling for evidence strength. Both DVs made a significant, unique contribution to confidence. However, in contrast to standard models, the magnitude of the winning DV was stronger.
November 3, 2025 at 9:12 PM
Despite the independent inputs, we found intrinsic negative correlations between the two DVs within trials, a signature of inhibition between the sensory-motor pathways supporting the two alternative choices. The strength of this correlation on each trial predicted confidence.
November 3, 2025 at 9:12 PM
We tracked the competition between neural decision variables (DVs) in the human frontal cortex, combining a novel task with atlas-based multivariate decoding of source-level MEG data to track two neural DVs for alternative choices in left and right premotor/motor cortex (PMd/M1).
November 3, 2025 at 9:12 PM
It fits the behavioral data better than a range of alternatives, and reproduces a number of behavioral and neural signatures, including the concurrently measured dynamics of the encoding of contrast samples in visual cortex.
November 3, 2025 at 6:06 PM
Our model combines sensory adaptation, leaky accumulation with feed-forward inhibition, and an asymmetric readout of the DVs in confidence formation.
November 3, 2025 at 6:06 PM
We next used single-trial regression to predict confidence from the winning and losing DVs, controlling for evidence strength. Both DVs made a significant, unique contribution to confidence. However, in contrast to standard models, the magnitude of the winning DV was stronger.
November 3, 2025 at 6:06 PM
Despite the independent inputs, we found intrinsic negative correlations between the two DVs within trials, a signature of inhibition between the sensory-motor pathways supporting the two alternative choices. The strength of this correlation on each trial predicted confidence.
November 3, 2025 at 6:06 PM
We tracked the competition between neural decision variables (DVs) in the human frontal cortex, combining a novel task with atlas-based multivariate decoding of source-level MEG data to track two neural DVs for alternative choices in left and right premotor/motor cortex (PMd/M1).
November 3, 2025 at 6:06 PM
It fits the behavioral data better than a range of alternatives, and reproduces a number of behavioral and neural signatures, including the concurrently measured dynamics of the encoding of contrast samples in visual cortex.
November 3, 2025 at 6:01 PM
Our model combines sensory adaptation, leaky accumulation with feed-forward inhibition, and an asymmetric readout of the DVs in confidence formation.
November 3, 2025 at 6:01 PM
We next used single-trial regression to predict confidence from the winning and losing DVs, controlling for evidence strength. Both DVs made a significant, unique contribution to confidence. However, in contrast to standard models, the magnitude of the winning DV was stronger.
November 3, 2025 at 6:01 PM
Despite the independent inputs, we found intrinsic negative correlations between the two DVs within trials, a signature of inhibition between the sensory-motor pathways supporting the two alternative choices. The strength of this correlation on each trial predicted confidence.
November 3, 2025 at 6:01 PM
We tracked the competition between neural decision variables (DVs) in the human frontal cortex, combining a novel task with atlas-based multivariate decoding of source-level MEG data to track two neural DVs for alternative choices in left and right premotor/motor cortex (PMd/M1).
November 3, 2025 at 6:01 PM
Ayelet Arazi - 📍 Poster 3.5 | Wed (July 16th):
Cortex-wide changes in neural dynamics in early-stage psychosis relate to GABA-A or NMDA receptor expression and function, and to clinical symptoms.
July 12, 2025 at 2:09 PM
Gina Monov - 📍 Poster 2.13 | Tue (July 15th):
Come explore our latest findings on cortical working memory dynamics in aging and MCI!
July 12, 2025 at 2:09 PM
Alessandro Toso - 📍 Poster 1.4 | Mon (July 14th):
Through pharmacological manipulations in humans, we showed that GABA-A and NMDA receptors shape perceptual decision-making at distinct timescales — within-trial and across-trial, respectively.
July 12, 2025 at 2:09 PM