David Michonneau
@dmichonneau.bsky.social
MD, PhD, hematologist @hopitalsaintlouis.bsky.social Professor of hematology @upcite.bsky.social @INSERM @institut-leucemie.bsky.social UMR1342
https://www.institut-leucemie.fr/linstitut-de-la-leucemie-recherche/immunologie-translationnelle/
https://www.institut-leucemie.fr/linstitut-de-la-leucemie-recherche/immunologie-translationnelle/
Happy to share our article in collaboration with @leeat-keren.bsky.social at Weizmann Institute of Science and @institut-leucemie.bsky.social A spatial atlas of human gastrointestinal acute GVHD reveals epithelial and immune dynamics underlying disease pathophysiology www.science.org/doi/10.1126/...
A spatial atlas of human gastrointestinal acute GVHD reveals epithelial and immune dynamics underlying disease pathophysiology
Multiplexed imaging of aGVHD GI biopsies revealed epithelial remodeling and alteration in immune composition, offering insight into disease pathology.
www.science.org
November 5, 2025 at 9:21 PM
Happy to share our article in collaboration with @leeat-keren.bsky.social at Weizmann Institute of Science and @institut-leucemie.bsky.social A spatial atlas of human gastrointestinal acute GVHD reveals epithelial and immune dynamics underlying disease pathophysiology www.science.org/doi/10.1126/...
doi.org/10.1084/jem....
Great collaboration with the group of Robert Zeiser linking microbiota-derived metabolites and central nervous system GVHD
Great collaboration with the group of Robert Zeiser linking microbiota-derived metabolites and central nervous system GVHD
Gut microbiota–derived TMAVA is a modulator of acute CNS-GVHD
In this study, we report that microbiota depletion exacerbates acute graft-versus-host disease in the central nervous system, driven by microglial activati
doi.org
July 10, 2025 at 8:20 AM
doi.org/10.1084/jem....
Great collaboration with the group of Robert Zeiser linking microbiota-derived metabolites and central nervous system GVHD
Great collaboration with the group of Robert Zeiser linking microbiota-derived metabolites and central nervous system GVHD
Great collaboration with Robert Zeiser @institut-leucemie.bsky.social @upcite.bsky.social @ap-hp.bsky.social @insermpresse.bsky.social Teduglutide for treatment-refractory severe intestinal acute graft-versus-host disease - a multicenter survey @springernature.com @BMT journal
rdcu.be/ehWV5
rdcu.be/ehWV5
Teduglutide for treatment-refractory severe intestinal acute graft-versus-host disease - a multicenter survey
Bone Marrow Transplantation - Teduglutide for treatment-refractory severe intestinal acute graft-versus-host disease - a multicenter survey
rdcu.be
April 16, 2025 at 7:36 AM
Great collaboration with Robert Zeiser @institut-leucemie.bsky.social @upcite.bsky.social @ap-hp.bsky.social @insermpresse.bsky.social Teduglutide for treatment-refractory severe intestinal acute graft-versus-host disease - a multicenter survey @springernature.com @BMT journal
rdcu.be/ehWV5
rdcu.be/ehWV5
Happy to share our last paper, published with @springernature.com in @BMTjournal, about the French experience with belumosudil in the treatment of steroid-resistant cGvHD. Best ORR 57.4% including 14.7% of CR in patients who previously received at least 2 LOT
rdcu.be/efZg9
rdcu.be/efZg9
Efficacy and safety of belumosudil for treatment of cGVHD: multicenter retrospective analysis of the French cohort of the compassionate use program, on behalf of the French Society of Bone Marrow Transplantation and Cellular Therapy
Bone Marrow Transplantation - Efficacy and safety of belumosudil for treatment of cGVHD: multicenter retrospective analysis of the French cohort of the compassionate use program, on behalf of the...
rdcu.be
April 1, 2025 at 6:20 PM
Happy to share our last paper, published with @springernature.com in @BMTjournal, about the French experience with belumosudil in the treatment of steroid-resistant cGvHD. Best ORR 57.4% including 14.7% of CR in patients who previously received at least 2 LOT
rdcu.be/efZg9
rdcu.be/efZg9
Congratulations to Sophie Le Grand for her very interesting paper in Hemasphere about the role of HLA evolutionary divergence score to predict outcome of prophylactic donor lymphocyte infusion after alloHSCT
doi.org/10.1002/hem3...
doi.org/10.1002/hem3...
HLA evolutionary divergence score after donor lymphocyte infusion following allogeneic hematopoietic stem cell transplantation
Donor lymphocyte infusion (DLI) prevents acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) relapses following hematopoietic stem cell transplantation. Given the life-threatening toxiciti....
doi.org
February 14, 2025 at 3:14 PM
Congratulations to Sophie Le Grand for her very interesting paper in Hemasphere about the role of HLA evolutionary divergence score to predict outcome of prophylactic donor lymphocyte infusion after alloHSCT
doi.org/10.1002/hem3...
doi.org/10.1002/hem3...
Systems-level immunomonitoring in children with solid tumors to enable precision medicine: Cell www.cell.com/cell/fulltex...
Systems-level immunomonitoring in children with solid tumors to enable precision medicine
In a population-based cohort of 191 children with diverse solid tumors, systems-level
analyses unravel immune variation with age and tumor type and provide a reference
for future precision immunothera...
www.cell.com
January 20, 2025 at 7:03 PM
Systems-level immunomonitoring in children with solid tumors to enable precision medicine: Cell www.cell.com/cell/fulltex...