Dan Michelson
@dmichelson.bsky.social
MD/PhD student at Harvard/MIT, fascinated by immune tolerance and autoimmunity
Beautiful work by @mmr2.bsky.social unlocking a new layer of immune regulation in the CNS — check it out!
1/ New in #ScienceImmunologyResearch! We explored how the brain maintains equilibrium with the immune system. Our focus? The key player in immune tolerance and tissue function regulation: regulatory T cells (Tregs). Let’s dive in! www.science.org/doi/10.1126/...
@immunoeditor.bsky.social
@immunoeditor.bsky.social
The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis
Meningeal regulatory T cells restrain local interferon-γ–producing lymphocytes, thereby safeguarding parenchymal brain homeostasis.
www.science.org
January 29, 2025 at 2:11 PM
Beautiful work by @mmr2.bsky.social unlocking a new layer of immune regulation in the CNS — check it out!
Excited to share our latest work on the thymus, out @cp-immunity.bsky.social! We define thymic mimetic cells in humans and show they are an evolutionarily ancient part of adaptive immunity. Terrific collab w Cardiac Surgery @bostonchildrens.bsky.social and Len Zon's lab
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
Cross-species analyses of thymic mimetic cells reveal evolutionarily ancient origins and both conserved and species-specific elements
Thymic mimetic cells are chimeras between medullary-thymic-epithelial cells (mTECs) and peripheral cell types. Huisman, Michelson, et al. perform high-resolution profiling of human mimetics, revealing a diversification of nerve and ionocyte mTECs and a massive expansion of muscle mTECs vis-à-vis mice. Comparison of human, mouse, and zebrafish mimetics reveals species-specific and species-conserved subtypes.
www.cell.com
December 27, 2024 at 4:30 PM
Excited to share our latest work on the thymus, out @cp-immunity.bsky.social! We define thymic mimetic cells in humans and show they are an evolutionarily ancient part of adaptive immunity. Terrific collab w Cardiac Surgery @bostonchildrens.bsky.social and Len Zon's lab
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...