Dustin Mayfield-Jones
@dmayfieldjones.bsky.social
Pathologically curious. Mostly dogs, systems & computational biology, philosophy, art, and caves. Interested in everything.
Reposted by Dustin Mayfield-Jones
We developed CrossFilt, a read-level, cross-species filtering approach that avoids these errors without sacrificing usable data. It outperforms all existing strategies and exposes just how much signal in comparative genomics has been misread.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
CrossFilt: A Cross-species Filtering Tool that Eliminates Alignment Bias in Comparative Genomics Studies
Comparative functional genomic studies are often affected by biased read mapping across species due to inter-species differences in genome structure, sequence composition, and annotation quality. We d...
doi.org
June 7, 2025 at 12:07 AM
We developed CrossFilt, a read-level, cross-species filtering approach that avoids these errors without sacrificing usable data. It outperforms all existing strategies and exposes just how much signal in comparative genomics has been misread.
doi.org/10.1101/2025...
doi.org/10.1101/2025...