David Cortez
@dkcortez.bsky.social
Professor and Chair, Department of Biochemistry
Reposted by David Cortez
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
biorxiv.org
November 12, 2025 at 9:26 PM
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Reposted by David Cortez
Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments
Homologous recombination (HR) deficiency upon Breast Cancer Gene 2 (BRCA2) loss arises from defects in the formation of RAD51 nucleoprotein filaments. We demonstrate that loss of the anti-recombinase ...
www.science.org
October 30, 2025 at 9:52 PM
Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Less than two weeks left to apply for our TWO tenure track assistant professor positions in Department of Biochemistry at Vanderbilt University School of Medicine. Basic Sciences
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Assistant Professor of Biochemistry at Vanderbilt University - Nashville, Tennessee job with Vanderbilt University School of Medicine | 12843515
Department of Biochemistry, School of Medicine—Basic Sciences
nam04.safelinks.protection.outlook.com
October 1, 2025 at 7:40 PM
Less than two weeks left to apply for our TWO tenure track assistant professor positions in Department of Biochemistry at Vanderbilt University School of Medicine. Basic Sciences
nam04.safelinks.protection.outlook.com?url=https%3A...
nam04.safelinks.protection.outlook.com?url=https%3A...
Reposted by David Cortez
🧪 Vanderbilt researchers are on a mission to “smooth out the bumps” in medicinal chemistry. Their new work addresses key inefficiencies that slow discovery and could accelerate the path from lab to clinic.
Learn more 👉 medschool.vanderbilt.edu/basic-scienc...
Learn more 👉 medschool.vanderbilt.edu/basic-scienc...
Vanderbilt research looks to smooth out bumps in medicinal chemistry processes
Vanderbilt researchers probe the mysteries of an enzyme that could be used as a tool in basic research and medicinal chemistry.
medschool.vanderbilt.edu
October 1, 2025 at 5:30 PM
🧪 Vanderbilt researchers are on a mission to “smooth out the bumps” in medicinal chemistry. Their new work addresses key inefficiencies that slow discovery and could accelerate the path from lab to clinic.
Learn more 👉 medschool.vanderbilt.edu/basic-scienc...
Learn more 👉 medschool.vanderbilt.edu/basic-scienc...
Reposted by David Cortez
Does anyone have another source besides BD for the B44 anti-brdu antibody or one that reacts with Idu and limited with Cldu. It’s badly back ordered.
September 19, 2025 at 2:24 PM
Does anyone have another source besides BD for the B44 anti-brdu antibody or one that reacts with Idu and limited with Cldu. It’s badly back ordered.
Reposted by David Cortez
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
www.nature.com/naturecareer...
Please repost!
August 28, 2025 at 6:34 AM
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
www.nature.com/naturecareer...
Please repost!
Reposted by David Cortez
We have openings for a postdoctoral training program on DNA Damage and Oncogenic Signaling. Our past trainees have been very successful. Apply by Aug 31 for full consideration. See link for details. www.imgs-coh.edu/postdoctoral...
Postdoctoral Training Programs
Funded by the National Cancer Institute (T32CA186895), the program at City of Hope provides exceptionally motivated, recent (2 years or less) postdoctoral fellows with scientific knowledge, researc
www.imgs-coh.edu
August 19, 2025 at 6:32 PM
We have openings for a postdoctoral training program on DNA Damage and Oncogenic Signaling. Our past trainees have been very successful. Apply by Aug 31 for full consideration. See link for details. www.imgs-coh.edu/postdoctoral...
Advertisements for 2 tenure-track assistant professor positions at Vanderbilt School of Medicine Basic Sciences:
www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Assistant Professor of Biochemistry at Vanderbilt University - Nashville, Tennessee job with Vanderbilt University School of Medicine | 12843515
Department of Biochemistry, School of Medicine—Basic Sciences
www.nature.com
August 14, 2025 at 4:57 PM
Advertisements for 2 tenure-track assistant professor positions at Vanderbilt School of Medicine Basic Sciences:
www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...
The Department of Biochemistry at Vanderbilt University (medschool.vanderbilt.edu/biochemistry/) is searching for TWO new Assistant Professors this year. Apply by October 15! apply.interfolio.com/171767
August 11, 2025 at 2:27 PM
The Department of Biochemistry at Vanderbilt University (medschool.vanderbilt.edu/biochemistry/) is searching for TWO new Assistant Professors this year. Apply by October 15! apply.interfolio.com/171767
Reposted by David Cortez
Thrilled to share our latest work. Great collab with Costanzo, Masson, Freire and Reyes' labs. Congrats to María José and coauthors
HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances www.science.org/doi/10.1126/...
HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances www.science.org/doi/10.1126/...
HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells
HMCES binding to nascent DNA blocks replication and kills homologous recombination–deficient cancer cells.
www.science.org
March 27, 2025 at 10:29 PM
Thrilled to share our latest work. Great collab with Costanzo, Masson, Freire and Reyes' labs. Congrats to María José and coauthors
HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances www.science.org/doi/10.1126/...
HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances www.science.org/doi/10.1126/...
Reposted by David Cortez
Very proud of this. It’s both the end and beginning of something new for me. My last paper in @dkcortez.bsky.social lab and my first co-corresponding author. Also truly a great supergroup including @freudlab.bsky.social @tmweaver.bsky.social and Roberts lab
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Contributing factors to the oxidation-induced mutational landscape in human cells - Nature Communications
8-oxoG is a common single-base DNA lesion caused by oxidative stress. Here, authors characterize the mutational signature of potassium bromate (KBrO3) exposure, the chromatin structural determinants o...
www.nature.com
December 23, 2024 at 9:27 PM
Very proud of this. It’s both the end and beginning of something new for me. My last paper in @dkcortez.bsky.social lab and my first co-corresponding author. Also truly a great supergroup including @freudlab.bsky.social @tmweaver.bsky.social and Roberts lab
www.nature.com/articles/s41...
www.nature.com/articles/s41...