Djivan Prentout
djivanp.bsky.social
Djivan Prentout
@djivanp.bsky.social
Postdoc in evolutionary genomics, studying the mechanisms of meiotic recombination at Columbia University (Przeworski lab)
14/ As expected in the absence of PRDM9 (tinyurl.com/2tjkar3j), recombination events overlap with CpG islands more often than expected by chance (with little or no effect of TSS).
September 6, 2024 at 3:20 PM
13/ In contrast, micro-chromosomes had significantly higher CO rates (4.21 cM/Mb), reflecting CO homeostasis. Both CO and NCO events were more uniformly distributed here than on macro-chromosomes.
September 6, 2024 at 3:20 PM
12/ Focusing on recombination, zebra finches show a sex-averaged CO rate of 1.05 cM/Mb on macro-chromosomes. COs are enriched near telomeres, while NCOs are more evenly spread. That too resembles the pattern in mammals.
September 6, 2024 at 3:19 PM
11/ Classifying mutations by developmental timing revealed a paternal germline mutation bias (1.7:1) in later stages of gametogenesis, but no sex difference in mutation rates during early development—similar to mammals (e.g., tinyurl.com/56zy44yh).
September 6, 2024 at 3:19 PM
10/ We estimate a sex-averaged mutation rate per bp per generation of 5.0 × 10⁻⁹ in zebra finches, which is comparable to other mammals and birds with similar generation times (tinyurl.com/w8wzkz4x).
September 6, 2024 at 3:19 PM
9/ To explore whether mutation and recombination parameters are similar in birds, we sequenced three-generation pedigrees of zebra finches, gathering information from 80 meiosis. We inferred 202 de novo mutations, 1,174 crossovers (COs), and 275 non-crossovers (NCOs).
September 6, 2024 at 3:19 PM
14/ As expected in the absence of PRDM9 (tinyurl.com/2tjkar3j), recombination events overlap with CpG islands more often than expected by chance (with little or no effect of TSS).
September 6, 2024 at 3:14 PM
13/ In contrast, micro-chromosomes had significantly higher CO rates (4.21 cM/Mb), reflecting CO homeostasis. Both CO and NCO events were more uniformly distributed here than on macro-chromosomes.
September 6, 2024 at 3:13 PM
12/ Focusing on recombination, zebra finches show a sex-averaged CO rate of 1.05 cM/Mb on macro-chromosomes. COs are enriched near telomeres, while NCOs are more evenly spread. That too resembles the pattern in mammals.
September 6, 2024 at 3:13 PM
11/ Classifying mutations by developmental timing revealed a paternal germline mutation bias (1.7:1) in later stages of gametogenesis, but no sex difference in mutation rates during early development—similar to mammals (e.g., tinyurl.com/56zy44yh).
September 6, 2024 at 3:13 PM
10/ We estimate a sex-averaged mutation rate per bp per generation of 5.0 × 10⁻⁹ in zebra finches, which is comparable to other mammals and birds with similar generation times (tinyurl.com/w8wzkz4x).
September 6, 2024 at 3:12 PM
9/ To explore whether mutation and recombination parameters are similar in birds, we sequenced three-generation pedigrees of zebra finches, gathering information from 80 meiosis. We inferred 202 de novo mutations, 1,174 crossovers (COs), and 275 non-crossovers (NCOs).
September 6, 2024 at 3:12 PM