Thanks - if you see something that needs correction of amendment please let us know.

We lost a towering figure in synthesis. It was a huge honor to serve as Amos’ colleague.

And here is a challenge to you sialyl aficionados: Why do newborns excrete polysialic acids? Where does it come from? From polysialylated GPCRs? Can’t be on that scale. I never found that answer.

Zbiral was also one of the first chemists to work on sialic acid. We had to obtain it through hydrolysis of meconium, the stuff newborns excrete in their first days. It contains large amounts of polysialic acid. Later, we switched to Chinese birds' nests. Fun times!

As efficacy switches, they also provide insight into how opioids can switch from weak to strong agonists!

Great collab with Seva Katritch, Cornelius Gati, and Josh Levitz.