Dinis Calado
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diniscalado.bsky.social
Dinis Calado
@diniscalado.bsky.social
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Senior Group Leader - The Francis Crick Institute @thecrick.bsky.social and The Babraham Institute @babrahaminst.bsky.social - Immunity and Cancer Laboratory #Bcell #germinalcenter #plasmacell #memoryBcell #lymphoma #myeloma
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diniscalado.bsky.social
New preprint from the lab! Lactate, a tumor-derived metabolite, blocks B cells from entering tumors and forming tertiary lymphoid structures (TLSs). Congratulations Victoire Boulat - in a great collaboration with Anita Grigoriadis! tinyurl.com/3vvk9kec #Immunology #TLS #CancerMetabolism #Bcells
October 6, 2025 at 4:48 PM
diniscalado.bsky.social
Want to see immune cells in 3D? We’ve published a protocol for 5-plex 3D imaging of whole lymph nodes, revealing germinal centers at single-cell resolution. So many possibilities ahead! Congratulations Victoire Boulat!

tinyurl.com/y9ekha8c

#Microscopy #Immunology #SpatialBiology
Quantitative 3D analysis of germinal centers, plasma cells, and follicular T cells post immunization. Representative image of 3D rendered surfaces created with Imaris including naïve B cells (blue), the T cell zone (green), follicular dendritic cell (FDC) network (white), germinal centers (red), follicular T cells (green) and plasma cells (magenta). Scale bar = 200 μm. Credit Victoire Boulat.
October 6, 2025 at 4:23 PM