Thank you to the patients and organ donors, collaborators and everyone that contributed to this study! @tedpricethepainguy.bsky.social @julietmwirigi.bsky.social @ish1789.bsky.social @utdpaincenter.bsky.social

Together, these insights highlight that while immune activation and fibrosis drive degeneration, there are also regenerative signals that could be therapeutically targeted early to preserve nerve health in DPN.

Key findings:
-In DPN, nerves shift toward inflammatory states.
-Sensory vs. mixed nerves respond differently.
-Progression from perineurial disruption → immune infiltration → fibrosis.
-mRNAs localize to axons, supporting RNA transport in nerve integrity.