David L. Goldblatt, MD.
@dgoldblatt.bsky.social
pending Pulm and Critical Care fellow @ UAB 7/2026. HHMI med fellow alumnus. Interested in #PCCM, #allergy, #asthma, & type 2 mucosal inflammation of the 🫁
Ah well i think we all understand that trade off 😆
August 28, 2025 at 12:08 AM
Ah well i think we all understand that trade off 😆
Somewhat surprised by the vitriol, he's not definitely wrong and he certainly doesn't say methods are unimportant. It seems pretty logical that if you are unimpressed (or don't understand) the results, the methods section would be useless (to you), no?
August 27, 2025 at 9:50 PM
Somewhat surprised by the vitriol, he's not definitely wrong and he certainly doesn't say methods are unimportant. It seems pretty logical that if you are unimpressed (or don't understand) the results, the methods section would be useless (to you), no?
Don't let primary doctors and big pharma tell you not to smoke. It's fine if you just follow up with a Pulmonologist every month for pulmonary function testing and low-dose CT scans. 🫁
August 17, 2025 at 8:24 PM
Don't let primary doctors and big pharma tell you not to smoke. It's fine if you just follow up with a Pulmonologist every month for pulmonary function testing and low-dose CT scans. 🫁
I don't think the average Arsenal amateur comentator is comprehending the magnitude of expense that a deal for Rodrygo would cost bsky.app/profile/dgol...
Madueke: £50m (fee) + £21m (£80k/wk x 5 years) = £71,000,000 (total cost)
Rodrygo: £90m (fee) + £50m (£190k/wk x 5 years) = £140,000,000 (total cost)
And this likely underestimates Rodrygo's cost as he may command £200k+/wk wages. #arsenal
Rodrygo: £90m (fee) + £50m (£190k/wk x 5 years) = £140,000,000 (total cost)
And this likely underestimates Rodrygo's cost as he may command £200k+/wk wages. #arsenal
July 11, 2025 at 12:19 AM
I don't think the average Arsenal amateur comentator is comprehending the magnitude of expense that a deal for Rodrygo would cost bsky.app/profile/dgol...
Do you know if this generalized across infection location and source (ie. Pna v bacteremia v soft-tissue v osteomyelitis)?
April 12, 2025 at 4:58 PM
Do you know if this generalized across infection location and source (ie. Pna v bacteremia v soft-tissue v osteomyelitis)?
Also may impair your ability to fight the next bug www.science.org/doi/10.1126/...
Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens
Measles virus infection can cause long-term damage to the immune system.
www.science.org
March 11, 2025 at 12:55 AM
Also may impair your ability to fight the next bug www.science.org/doi/10.1126/...
www.thelancet.com/journals/lan...
Approximately 10% increase in new onset DM2, however importsnt to remeber that dyslipidemia and metabolic syndrome are also associated so theres likely some confounding. Benefit of statin outweights DM risk by alot.
Approximately 10% increase in new onset DM2, however importsnt to remeber that dyslipidemia and metabolic syndrome are also associated so theres likely some confounding. Benefit of statin outweights DM risk by alot.
Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis
Statins cause a moderate dose-dependent increase in new diagnoses of diabetes that is consistent with a small upwards shift in glycaemia, with the majority of new diagnoses of diabetes occurring in people with baseline glycaemic markers that are close to the diagnostic threshold for diabetes. Importantly, however, any theoretical adverse effects of statins on cardiovascular risk that might arise from these small increases in glycaemia (or, indeed, from any other mechanism) are already accounted for in the overall reduction in cardiovascular risk that is seen with statin therapy in these trials.
www.thelancet.com
January 2, 2025 at 9:55 PM
www.thelancet.com/journals/lan...
Approximately 10% increase in new onset DM2, however importsnt to remeber that dyslipidemia and metabolic syndrome are also associated so theres likely some confounding. Benefit of statin outweights DM risk by alot.
Approximately 10% increase in new onset DM2, however importsnt to remeber that dyslipidemia and metabolic syndrome are also associated so theres likely some confounding. Benefit of statin outweights DM risk by alot.
Potential, not likely, and possibly not even clinically relevant
January 2, 2025 at 9:51 PM
Potential, not likely, and possibly not even clinically relevant
The decision to add a particular test would depend on that specific test. ICU patients have already tested quite a bit. The best way to save money on ICU patients is to get them out of the ICU faster.
December 7, 2024 at 11:46 PM
The decision to add a particular test would depend on that specific test. ICU patients have already tested quite a bit. The best way to save money on ICU patients is to get them out of the ICU faster.
"Precision medicine" is a very broad term, meaning nothing specific, so I am unsure what costs you're referring to, but I see negligible costs or any at all. If you're referring to oncology and genetic profiling,this isnt that. This is primarily referring to clinical data and hemodynamics.
December 7, 2024 at 11:26 PM
"Precision medicine" is a very broad term, meaning nothing specific, so I am unsure what costs you're referring to, but I see negligible costs or any at all. If you're referring to oncology and genetic profiling,this isnt that. This is primarily referring to clinical data and hemodynamics.
I believe this transition will occur within my lifetime and its impact will be significantly more profound than the immune-oncology revolution (which...was also profound)
December 7, 2024 at 8:59 PM
I believe this transition will occur within my lifetime and its impact will be significantly more profound than the immune-oncology revolution (which...was also profound)
Interesting, I remember thinking the intercellular machinery for peptide processing involved in cross-presentation was fairly advanced and important in serving regulatory functions, but perhaps I misunderstood
December 5, 2024 at 10:12 PM
Interesting, I remember thinking the intercellular machinery for peptide processing involved in cross-presentation was fairly advanced and important in serving regulatory functions, but perhaps I misunderstood
I would imagine the overall result of option 1 being a chaotic immune response with some outright dangerous possibilities. It probably makes sense why the immune system did not evolve to permit this pathway to be readily accessible.
December 5, 2024 at 9:40 PM
I would imagine the overall result of option 1 being a chaotic immune response with some outright dangerous possibilities. It probably makes sense why the immune system did not evolve to permit this pathway to be readily accessible.
It's probably time to upgrade this hypothesis, as it looks more likely to be plausible and definitely supports the continued use of azithromycin in undifferentiated acute COPD exacerbations.
December 5, 2024 at 9:22 PM
It's probably time to upgrade this hypothesis, as it looks more likely to be plausible and definitely supports the continued use of azithromycin in undifferentiated acute COPD exacerbations.
Because no one has ever really demonstrated to me how this was likely to occur, I had probably filed this away as "unlikely to be true" in my brain. These data suggest that AZM has direct effects on human type 1 immunity in a sterile model.
December 5, 2024 at 9:22 PM
Because no one has ever really demonstrated to me how this was likely to occur, I had probably filed this away as "unlikely to be true" in my brain. These data suggest that AZM has direct effects on human type 1 immunity in a sterile model.
If you dissolve the lung, can't have lung pathology
Tkt Smart GIF
ALT: Tkt Smart GIF
media.tenor.com
October 11, 2024 at 10:55 AM
If you dissolve the lung, can't have lung pathology