Yesterday we saw that blocking glucagon was really bad!!! Today we'll discuss what happens when you agonize it instead. Yes it'll raise glucose, but only briefly! Grab a Coke, and let's 🧵 and see the future of medicine together

Glucagon antagonist? Glucagon agonist? Which is better? Why are all the multi-agonist peptides choosing to add glucagon as an agonist? Well let’s review the risks, & major benefits of antagonists tonight, the agonists will be tomorrow! This is gonna be somewhat counter-intuitive! Let’s go 🧵🧵 1/

Hyperaminoacidemia from interrupted glucagon signaling increases pancreatic acinar cell proliferation and size via mTORC1 and YAP pathways 🧪 www.sciencedirect.com/science/arti...