Chris Deppmann
@deppmann.bsky.social
Neuroscientist 🧠 | Professor 📚 | Biochemistry Enthusiast 🧪 |
🔍 Mission: Train future giants in science while standing on the shoulders of those before me. 🌱
www.deppmannlab.com
🔍 Mission: Train future giants in science while standing on the shoulders of those before me. 🌱
www.deppmannlab.com
Hot off the press from my lab & @zunderlab: extrinsic apoptosis & necroptosis play tag-team in brain dev! Jiachen Shi crushed it with single-cell mass cytometry.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Extrinsic Apoptosis and Necroptosis in Telencephalic Development: A Single-Cell Mass Cytometry Study
Regulated cell death is integral to sculpting the developing brain, yet the relative contributions of extrinsic apoptosis and necroptosis remain unclear. Here, we leverage single-cell mass cytometry (...
www.biorxiv.org
March 9, 2025 at 6:06 PM
Hot off the press from my lab & @zunderlab: extrinsic apoptosis & necroptosis play tag-team in brain dev! Jiachen Shi crushed it with single-cell mass cytometry.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Congrats to Sushanth Kumar on his first corresponding author paper in Glia! 🎉👏
Using single-cell mass cytometry—like doing Western blots for every individual cell—this study maps the unique signaling signatures of microglia during viral and bacterial infections.
doi.org/10.1002/glia...
Using single-cell mass cytometry—like doing Western blots for every individual cell—this study maps the unique signaling signatures of microglia during viral and bacterial infections.
doi.org/10.1002/glia...
Characterizing Microglial Signaling Dynamics During Inflammation Using Single‐Cell Mass Cytometry
Microglia play a critical role in maintaining central nervous system (CNS) homeostasis and display remarkable plasticity in their response to inflammatory stimuli. However, the specific signaling pro....
doi.org
January 9, 2025 at 11:58 AM
Congrats to Sushanth Kumar on his first corresponding author paper in Glia! 🎉👏
Using single-cell mass cytometry—like doing Western blots for every individual cell—this study maps the unique signaling signatures of microglia during viral and bacterial infections.
doi.org/10.1002/glia...
Using single-cell mass cytometry—like doing Western blots for every individual cell—this study maps the unique signaling signatures of microglia during viral and bacterial infections.
doi.org/10.1002/glia...
Reposted by Chris Deppmann
GLP-1 receptor agonists (GLP-1RAs) are transforming the treatment of obesity and diabetes (and more). Our recent pre-print examined next-gen small molecules mimicking GLP-1, using humanized mouse models to uncover how they interact with brain circuits driving food consumption. 1/15
December 18, 2024 at 5:39 PM
GLP-1 receptor agonists (GLP-1RAs) are transforming the treatment of obesity and diabetes (and more). Our recent pre-print examined next-gen small molecules mimicking GLP-1, using humanized mouse models to uncover how they interact with brain circuits driving food consumption. 1/15
Huge congrats to Lizzy et al for showing how next-gen GLP1R drugs hack your amygdala to make your dopamine neurons say 'nah' to that second slice! 🧠🍰❌
Another great collab with @aguler.bsky.social 🔥"https://www.biorxiv.org/content/10.1101/2024.12.12.628169v1
Another great collab with @aguler.bsky.social 🔥"https://www.biorxiv.org/content/10.1101/2024.12.12.628169v1
December 18, 2024 at 4:13 PM
Huge congrats to Lizzy et al for showing how next-gen GLP1R drugs hack your amygdala to make your dopamine neurons say 'nah' to that second slice! 🧠🍰❌
Another great collab with @aguler.bsky.social 🔥"https://www.biorxiv.org/content/10.1101/2024.12.12.628169v1
Another great collab with @aguler.bsky.social 🔥"https://www.biorxiv.org/content/10.1101/2024.12.12.628169v1
Exciting news from our lab! Amy, Eli, and the team just published a single-cell mass cytometry atlas of the developing mouse brain! 🧠 24M cells profiled, 85 unique clusters identified—shedding light on protein-level cell state dynamics. Congrats, team! rdcu.be/d30MN
A single-cell mass cytometry-based atlas of the developing mouse brain
Nature Neuroscience - In recent years, valuable mRNA-based developmental atlases of the mouse brain have been made available. Here, the authors use single-cell mass cytometry to build a...
rdcu.be
December 18, 2024 at 11:37 AM
Exciting news from our lab! Amy, Eli, and the team just published a single-cell mass cytometry atlas of the developing mouse brain! 🧠 24M cells profiled, 85 unique clusters identified—shedding light on protein-level cell state dynamics. Congrats, team! rdcu.be/d30MN
Reposted by Chris Deppmann
Excited to share our latest findings, now published @NatureNeuro www.nature.com/articles/s41...
We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties.
Threads will follow!
We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties.
Threads will follow!
December 2, 2024 at 10:02 AM
Excited to share our latest findings, now published @NatureNeuro www.nature.com/articles/s41...
We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties.
Threads will follow!
We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties.
Threads will follow!
Reposted by Chris Deppmann
Would you prefer to lead a lab alone or together with a science buddy? How interesting would be a research institute where joint labs are the standard?!
November 23, 2024 at 12:42 AM