Thanks so much Keri!!

Thanks!

Thanks so much Kathy!

Thanks! Enjoying working together and looking forward to more collaboration!

Thanks so much! We are excited about it and hope it is broadly useful.

Thanks Matt!

Grateful for funding from NINDS which made this possible!!! And for our outstanding team and collaborators including Phoebe Lee, Lucas Serdar, Stephany Perez-Sanchez, Virginia Fernandez, and @borrell-lab.bsky.social.

Finally, we develop a new CRISPR-based method for spatial and temporal manipulation of mRNAs. We hope our tool will propel new discoveries across cells of the nervous system.

Our study highlights conserved and unique principles of mRNA localization across the nervous system, and associated with neurodevelopment disease. This generates new hypotheses about functions of radial glia. From this we discover Dynein components control radial glia morphology and interneurons.

Radial glia have complex morphologies that are critical for their function. Yet, how they are subcellularly controlled to dictate cortical development remains largely elusive. We discover over 800 transcripts sub-cellularly enriched in radial glia basal compartments.

Thanks Mariah!

Thanks Matt!!

Thanks Madeline!!

Grateful to additional fantastic co-authors including
@jingliu1129.bsky.social , Katie Lam, Samantha Skavicus, Nick Heaton, Victoria Kapp. Also enormously grateful to funding from NIMH which made our discoveries possible.

Finally in a fantastic collaboration with Katie Pollard and Katie Gjoni, we discover nearby structural variants that stabilize its chromatin loops with these target genes, suggesting co-evolution of human-specific DNA changes.

It influences neurogenesis by controlling expression of two key target genes, ETV5 and TRA2B, through a positive feedback loop.

Using genomically-edited human and chimpanzee organoids, and mouse models, we show the human enhancer boosts progenitor proliferation and neuron production. We further show that human HAR1984 is sufficient to induce cortical folding in an otherwise smooth (lissencephalic) brain!