Debashis Dhara
@debashisdhara.bsky.social
Postdoc, University of Oxford
Glad to share our new paper online! Splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages academic.oup.com/nar/article/...
#RNAtherapeutics #Oligonucleotides #SpliceSwitching #Phosphorothioate #NucleicAcids
#RNAtherapeutics #Oligonucleotides #SpliceSwitching #Phosphorothioate #NucleicAcids
Biophysical and biological properties of splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages
Abstract. Antisense oligonucleotides hold great promise in the treatment of disease, but their efficacy is limited by modest bioavailability and toxicity.
academic.oup.com
November 29, 2025 at 8:37 PM
Glad to share our new paper online! Splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages academic.oup.com/nar/article/...
#RNAtherapeutics #Oligonucleotides #SpliceSwitching #Phosphorothioate #NucleicAcids
#RNAtherapeutics #Oligonucleotides #SpliceSwitching #Phosphorothioate #NucleicAcids
Reposted by Debashis Dhara
This review is from @hollensteinlab.bsky.social, @debashisdhara.bsky.social and Laurence Mulard at @pasteur.fr
'Natural, modified and conjugated carbohydrates in nucleic acids'
#OpenAccess 🔓
pubs.rsc.org/en/content/a...
'Natural, modified and conjugated carbohydrates in nucleic acids'
#OpenAccess 🔓
pubs.rsc.org/en/content/a...
Natural, modified and conjugated carbohydrates in nucleic acids
Storage of genetic information in DNA occurs through a unique ordering of canonical base pairs. However, this would not be possible in the absence of the sugar–phosphate backbone which is essential fo...
pubs.rsc.org
March 3, 2025 at 10:31 AM
This review is from @hollensteinlab.bsky.social, @debashisdhara.bsky.social and Laurence Mulard at @pasteur.fr
'Natural, modified and conjugated carbohydrates in nucleic acids'
#OpenAccess 🔓
pubs.rsc.org/en/content/a...
'Natural, modified and conjugated carbohydrates in nucleic acids'
#OpenAccess 🔓
pubs.rsc.org/en/content/a...
Happy to share our latest review article on carbohydrates in nucleic acids! @chemsocrev.bsky.social pubs.rsc.org/en/content/a...
Natural, modified and conjugated carbohydrates in nucleic acids
Storage of genetic information in DNA occurs through a unique ordering of canonical base pairs. However, this would not be possible in the absence of the sugar–phosphate backbone which is essential fo...
pubs.rsc.org
February 12, 2025 at 8:31 PM
Happy to share our latest review article on carbohydrates in nucleic acids! @chemsocrev.bsky.social pubs.rsc.org/en/content/a...