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Reposted
Years of work, finally out! Nuclear Pore Complexes (NPCs) are the gateways to the nucleus, but how can they be both rapid and picky, even for very large cargoes? To answer this question, we built the most detailed data-driven model to date of transport through NPCs. /
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Integrative mapping reveals molecular features underlying the mechanism of nucleocytoplasmic transport | PNAS
Nuclear pore complexes (NPCs) enable rapid, selective, and robust nucleocytoplasmic
transport. To explain how transport emerges from the system com...
www.pnas.org
October 19, 2025 at 7:12 AM
Years of work, finally out! Nuclear Pore Complexes (NPCs) are the gateways to the nucleus, but how can they be both rapid and picky, even for very large cargoes? To answer this question, we built the most detailed data-driven model to date of transport through NPCs. /
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
A recent paper shows that channel confinement dramatically changes the properties of peptides analogous to those in the nuclear pore complex with important implications for fuctional models. biorxiv.org/lookup/doi/1...
Effects of Nanopore Confinement on the Conformational, Dynamical, and Self-Assembly Properties of an FG-Repeat Peptide
The central channels of nuclear pore complexes (NPCs) in eukaryotic cells contain a high concentration of protein chains with characteristic phenylalanine-glycine motifs, called FG-repeat domains, tet...
biorxiv.org
October 24, 2025 at 6:22 PM
A recent paper shows that channel confinement dramatically changes the properties of peptides analogous to those in the nuclear pore complex with important implications for fuctional models. biorxiv.org/lookup/doi/1...