David S. Butcher
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davidbutcher.bsky.social
David S. Butcher
@davidbutcher.bsky.social
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Research faculty in the Ion Cyclotron Resonance facility of the National High Magnetic Field Laboratory, focusing on top-down proteomics. https://orcid.org/0000-0002-1268-4150
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Reposted by David S. Butcher
uff-fsu.bsky.social
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April 17, 2025 at 7:02 PM
Reposted by David S. Butcher
verenaresch.bsky.social
I sometimes forget how flexible proteins are. It becomes really apparent when you use NMR states for an animation. That poor cofactor is getting pushed around a lot 😅

#sciart #blender3d #biocatalysis
November 25, 2024 at 5:14 PM
Reposted by David S. Butcher
delalamo.xyz
Yet more evidence that transfer learning of sequence-only PLMs does not benefit from scale beyond 650M params 🧵
Fig. 3. Impact of ESM Model size on transfer learning. LassoCV regression results using ESM mean embeddings for 35 DMS datasets. The x-axis represents different ESM model sizes: ESM1v 650M (orange) and ESM2 8M, 35M, 150M, 650M, 3B, and 15B (blues). The y-axis displays R^2 for each task.
November 25, 2024 at 7:34 AM
Reposted by David S. Butcher
metamorpheus.bsky.social
My enthusiasm for really expensive black box proteomics software is hard to measure on any sort of reasonable scale.
a man with glasses looks through a magnifying glass at something
ALT: a man with glasses looks through a magnifying glass at something
media.tenor.com
November 26, 2024 at 5:08 PM