David J. Cutler
David J. Cutler
@davecutler.bsky.social
I am a population geneticist.
Did you ever wonder how good any disease predictor based only on genetic data could be? Answer: it is a function of the heritability of the markers used, and might not be very high, without ~all~ the genetic variants identified. Figure 5. www.pivotscipub.com/hpgg/4/3/000...
The Quantitative Genetics of Human Disease: 2 Polygenic Risk Scores
The Quantitative Genetics of Human Disease: 2 Polygenic Risk Scores
www.pivotscipub.com
August 20, 2024 at 5:30 PM
Did you ever wonder why polygenic risk scores seem so hard to interpret across populations? Answer: it is almost all due to allele frequency and LD differences. www.pivotscipub.com/hpgg/4/3/000...
The Quantitative Genetics of Human Disease: 2 Polygenic Risk Scores
The Quantitative Genetics of Human Disease: 2 Polygenic Risk Scores
www.pivotscipub.com
August 20, 2024 at 5:28 PM
This monster of paper is entirely open source, so if you find it at all useful, please share it with your friends and trainees.
 pivotscipub.com/hpgg/3/4/000...
December 8, 2023 at 6:56 PM
Do you know what an additive by additive genetic interaction is? If you want to see a definition and a description for how to calculate such a thing for both quantitative and binary traits try  pivotscipub.com/hpgg/3/4/000...
December 8, 2023 at 6:50 PM
Have you ever wanted to know how to calculate heritability for a human disease? Have you ever wanted to know how to convert human genetics quantities like odds ratios or penetrance into their quantitative genetics equivalents?
 pivotscipub.com/hpgg/3/4/000...
December 8, 2023 at 6:47 PM
Have you ever wanted to see a derivation of fundamental quantitative genetics results without any assumption of normal distributions?  pivotscipub.com/hpgg/3/4/000...
December 8, 2023 at 6:45 PM