We believe there is no such thing as a negative result - JAMA Editors agree, thankfully 👏

@davidaharrison.bsky.social ?

Detailed trial process evaluation coming soon - at least what was possible during the complexity of an unexpected global pandemic and the aftershock.

Kathy announced it day 2 - good move!

Thanks - I had dark hair at the start of this!

This is the very first part of a programme. You're will hear more about our trial process evaluation and health economic analysis early in 2025 - then a good go at bringing our data into the pool of open label trial results - remember our work also included intervention concealment.

Thanks Nick. Our motivation was to address a tight brief from the public funded, government run UK research sector, with mandated 3 arm rct including standard care and one of each, daily pct or crp discontinuation protocols. We wanted to add more quality to the evidence and, of course, MA in time.

Thanks Ben, explanation - data linkage with NHS was a nightmare, got this from our team on the way to the conference - you couldn't make it up. We'll find a way to disseminate somehow - but the 90-all cause is in the secondary outcomes.

... and also meet our funder's pre-specified brief of testing two biomarker protocols in a 3 arm rct.

Agree Lars, it's going to be how we get to understand all of this to progress care. I would also say that there are a number of open label pct trials out there that will need to be considered as a body of work - our trial was an attempt to add to knowledge with an intervention concealment strategy

Due to persistent challenges with data linkage for trials in the UK, we didn't get this KM plot into the final online manuscript, but we were able to show @CCR Down Under yesterday . The end of the 90-day follow-up was in September 2024.

See above Jack

It's a superiority trial with sample size estimate to detect a 1 day reduction in total antibiotic duration to day 28 for intervention(s) vs control. We were able to monitor safety (28-day all cause mortality)for this sample size with the stated NI margin. + 90-day all cause mortality was reported.