Daria Jensen
@dariaeajensen.bsky.social
Postdoc @MPI_CBS @AgingObesity @UKL. | interested in diet, healthy ageing, connectivity, big data, memory and partneracrobatics.
Thank you for sharing our study!
March 13, 2025 at 9:41 AM
Thank you for sharing our study!
In terms of other lifestyle factors, we have accounted for them in the study as 'confounders'. Therefore, effects are independent of those.
March 12, 2025 at 5:08 PM
In terms of other lifestyle factors, we have accounted for them in the study as 'confounders'. Therefore, effects are independent of those.
We fully agree that further research has to be done in woman studies, therefore replication of those effects in more balanced cohorts are the next planned step!
March 12, 2025 at 5:08 PM
We fully agree that further research has to be done in woman studies, therefore replication of those effects in more balanced cohorts are the next planned step!
Thank you for your comments. Indeed the Whitehall II study has the limitation of being predominantly male, however the Whitehall II study is one of the largest longitudinal cohorts which was the main benefit of this study.
March 12, 2025 at 5:08 PM
Thank you for your comments. Indeed the Whitehall II study has the limitation of being predominantly male, however the Whitehall II study is one of the largest longitudinal cohorts which was the main benefit of this study.
8/ 👥 Thank you also to the fantastic co-author’s contributions Tasnime Akbaraly, Michelle Jansen, Archana Singh-Manoux, Mika Kivimäki EnikoZsoldos, the @whitehall2study.bsky.social team and the reviewers who made this paper better.
March 12, 2025 at 4:31 PM
8/ 👥 Thank you also to the fantastic co-author’s contributions Tasnime Akbaraly, Michelle Jansen, Archana Singh-Manoux, Mika Kivimäki EnikoZsoldos, the @whitehall2study.bsky.social team and the reviewers who made this paper better.
7/ 🙌 I am really happy and grateful for the team behind this paper and all the valuable advice and mentorship throughout the years!
March 12, 2025 at 4:31 PM
7/ 🙌 I am really happy and grateful for the team behind this paper and all the valuable advice and mentorship throughout the years!
6/ 🧠💪 Maintaining a higher diet quality and a reduced waist-to-hip ratio during midlife are crucial for enhancing brain connectivity and cognitive function in older age. These findings underscore the importance of lifestyle interventions in midlife to promote long-term brain health.
March 12, 2025 at 4:31 PM
6/ 🧠💪 Maintaining a higher diet quality and a reduced waist-to-hip ratio during midlife are crucial for enhancing brain connectivity and cognitive function in older age. These findings underscore the importance of lifestyle interventions in midlife to promote long-term brain health.
5/ 📈->🧠-> 🧩 Higher WHR in midlife was associated with lower cognitive performance scores, particularly in memory and executive function. This association was partially mediated by changes in WM connectivity (i.e. FA radial and mean diffusivity).
March 12, 2025 at 4:31 PM
5/ 📈->🧠-> 🧩 Higher WHR in midlife was associated with lower cognitive performance scores, particularly in memory and executive function. This association was partially mediated by changes in WM connectivity (i.e. FA radial and mean diffusivity).
4/ 📈🧠 Higher WHR in midlife was associated with higher diffusivity covering up to 26 % of the total WM tracts, and lower FA of the WM skeleton.
March 12, 2025 at 4:31 PM
4/ 📈🧠 Higher WHR in midlife was associated with higher diffusivity covering up to 26 % of the total WM tracts, and lower FA of the WM skeleton.
3/🍎🧠 Better diet quality was linked to enhanced functional connectivity between the hippocampus and occipital lobe & cerebellum. Higher 🍎 over time was related to better WM integrity in several tracts, indicating healthier brain structure.
March 12, 2025 at 4:31 PM
3/🍎🧠 Better diet quality was linked to enhanced functional connectivity between the hippocampus and occipital lobe & cerebellum. Higher 🍎 over time was related to better WM integrity in several tracts, indicating healthier brain structure.
2/ 📊 Our study involved 664 participants, with a mean age of 48 at baseline and 70 at the time of MRI. We observed that while diet quality (measured using the Alternative Healthy Eating Index-2010 score) remained stable over 11 years, WHR increased nonlinearly 📈 over 21 years.
March 12, 2025 at 4:31 PM
2/ 📊 Our study involved 664 participants, with a mean age of 48 at baseline and 70 at the time of MRI. We observed that while diet quality (measured using the Alternative Healthy Eating Index-2010 score) remained stable over 11 years, WHR increased nonlinearly 📈 over 21 years.
March 20, 2024 at 8:48 AM
We cannot publish participants’ data itself because it is part of HCP (but you can apply for access here: www.humanconnectome.org). But source data for the figures, including the parcellation and the code is available here: osf.io/bq3fd
Thanks for reading until here, we hope you enjoyed this thread!
Thanks for reading until here, we hope you enjoyed this thread!
Nuclei-specific hypothalamus networks predict a dimensional marker of stress in humans
Source data and code related to Jensen et al., Nat Comms, 2024. For HCP users, this code should be sufficient to replicate figures, analyses and results presented in the manuscript and supplementary i...
osf.io
March 19, 2024 at 9:01 AM
We cannot publish participants’ data itself because it is part of HCP (but you can apply for access here: www.humanconnectome.org). But source data for the figures, including the parcellation and the code is available here: osf.io/bq3fd
Thanks for reading until here, we hope you enjoyed this thread!
Thanks for reading until here, we hope you enjoyed this thread!
Thank you so much to my amazing DPhil supervisors, the @HumanConnectome team and the reviewers (Seiki Konishi, Martin Paulus and Philipp Säman) who made this paper better.
March 19, 2024 at 9:01 AM
Thank you so much to my amazing DPhil supervisors, the @HumanConnectome team and the reviewers (Seiki Konishi, Martin Paulus and Philipp Säman) who made this paper better.
The advantage of looking at a small, circumscribed network is that it might be possible, in the future, to alter affected hypothalamus networks using targeted interventions, e.g. using transcranial ultrasonic neurostimulation, in patients struggling with stress disorders.
March 19, 2024 at 9:00 AM
The advantage of looking at a small, circumscribed network is that it might be possible, in the future, to alter affected hypothalamus networks using targeted interventions, e.g. using transcranial ultrasonic neurostimulation, in patients struggling with stress disorders.
We characterised hypothalamus connectivity at the scale of its individual subnuclei. Our stress predictions were behaviourally specific and improved by nucleus level anatomical resolution (as opposed to whole hypothalamus resolution).
March 19, 2024 at 9:00 AM
We characterised hypothalamus connectivity at the scale of its individual subnuclei. Our stress predictions were behaviourally specific and improved by nucleus level anatomical resolution (as opposed to whole hypothalamus resolution).
Rather than identifying an extensive network for maximal prediction accuracy, we focused on a small network centred on the hypothalamus which involved less than 2% of brain ordinates and 0.0015% of brain edges.
March 19, 2024 at 9:00 AM
Rather than identifying an extensive network for maximal prediction accuracy, we focused on a small network centred on the hypothalamus which involved less than 2% of brain ordinates and 0.0015% of brain edges.
We show using multiple robust and replicable analyses that it is possible to relate nuclei-precise hypothalamus functional connectivity with other subcortical structures to stress in humans.
March 19, 2024 at 9:00 AM
We show using multiple robust and replicable analyses that it is possible to relate nuclei-precise hypothalamus functional connectivity with other subcortical structures to stress in humans.
We did that by using i.e., questionnaire scores related to stress experienced over the last week, month or “in general” to obtain one dimensional marker of stress using factor analysis.
March 19, 2024 at 8:59 AM
We did that by using i.e., questionnaire scores related to stress experienced over the last week, month or “in general” to obtain one dimensional marker of stress using factor analysis.
We then characterized these nuclei’s functional connectivity with other subcortical regions of interest, such as amygdala, and nuclei associated with brainstem neurotransmitter systems.
March 19, 2024 at 8:57 AM
We then characterized these nuclei’s functional connectivity with other subcortical regions of interest, such as amygdala, and nuclei associated with brainstem neurotransmitter systems.
Because the hypothalamus contains anatomically and functionally distinct nuclei, we first created a detailed parcellation of the hypothalamus into seven distinct, replicable, nuclei based on resting-state data (available here: osf.io/bq3fd).
March 19, 2024 at 8:57 AM
Because the hypothalamus contains anatomically and functionally distinct nuclei, we first created a detailed parcellation of the hypothalamus into seven distinct, replicable, nuclei based on resting-state data (available here: osf.io/bq3fd).
Here we used 3T and 7T resting-state fMRI data from nearly 500 people from the @HumanConnectome and examined whether hypothalamus functional connectivity relates to stress.
March 19, 2024 at 8:56 AM
Here we used 3T and 7T resting-state fMRI data from nearly 500 people from the @HumanConnectome and examined whether hypothalamus functional connectivity relates to stress.