That is fascinating! I look forward to seeing your results.

Very interesting results. I am not so familiar with the goat and reindeer models, but do individuals with higher pTau present behavioral or motor changes? Looking forward to your upcoming publication

This can’t be real. It has to be a joke in poor taste... pun not fully intended.

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grants.nih.gov/news-events/...

Science is advancing, but the future of these treatments depends on sustainable development models. If lifesaving therapies can’t survive traditional commercial pathways, what should replace them? A bigger role for nonprofits, public institutions, and governments?

#GeneTherapy #FDA #ScienceNews

For example, studying microbes in hot springs seems far removed from medicine. But those basic observations laid the foundation for breakthroughs in genomics, cancer research, and led to billion-dollar biotech innovations. Honestly, they should be required listening in school.

As scientists, we need to do a better job communicating the value of basic research to the general public—the kind where we may not see an immediate application, but which can lead to revolutionary advances. #ScienceTwitter #BasicResearch #STEM

4. Our iPSC-derived model successfully mimicked neuronal activity response and revealed a novel pathway altered in prion disease. Offering a new platform to study signaling in prion disease.

3. Our iN model recapitulates Arc/Arg3.1 response and reveals alterations in the EGF receptor and phospholipase C. These changes were also observed in the cerebral cortex of prion-infected mice.

2. I developed a model to study acute signaling following PrPC stimulation using human iPSC-derived excitatory neurons (iNs) with a known PrPSc-mimetic antibody.

1. In human #CJD and #GSS frontal cortex, we identify an increase in the immediate early gene, Arc/Arg3.1, suggestive of neuronal hyperactivity.