Dan Isom
@danisomlab.bsky.social
University of Miami, FL: molecular and cellular basis of proton sensing, synBio for health/energy and drug discovery, novel data science for protein structure-function informatics, and AI: https://www.isomlab.com
These mutations mimic protonation (i.e., activation) and, along with abolishing Na+ negative allosteric modulation, were intended to fully activate GPR4, 65, and 68 precisely as they did
January 3, 2025 at 2:10 PM
These mutations mimic protonation (i.e., activation) and, along with abolishing Na+ negative allosteric modulation, were intended to fully activate GPR4, 65, and 68 precisely as they did
There is a misunderstanding here. These mutations were not designed to abolish proton-mediated activation but to achieve the exact opposite based on the predicted physical chemistry and self-energy considerations.
January 3, 2025 at 2:10 PM
There is a misunderstanding here. These mutations were not designed to abolish proton-mediated activation but to achieve the exact opposite based on the predicted physical chemistry and self-energy considerations.
That bill is strangely pleasing.
August 19, 2023 at 2:08 AM
That bill is strangely pleasing.
Otterly astounding ;)
August 19, 2023 at 2:03 AM
Otterly astounding ;)