Daniel Trettel
@danieltrettel.bsky.social
Building structure in bacteria. LANL scientist and biochemist guy.
Rare earth elements power our green tech, but their extraction is anything but “green”. Our new preprint engineered a biological alternative using protein phase separation.
Full preprint: www.biorxiv.org/content/10.6...
Full preprint: www.biorxiv.org/content/10.6...
Metal-Triggered Rheological Switching in Engineered Lanmodulin Condensates
Reliable recovery of rare earth elements (REEs) is increasingly important for energy and communication technologies, yet current separation methods rely on harsh chemistries and are difficult to scale...
www.biorxiv.org
December 30, 2025 at 2:00 PM
Rare earth elements power our green tech, but their extraction is anything but “green”. Our new preprint engineered a biological alternative using protein phase separation.
Full preprint: www.biorxiv.org/content/10.6...
Full preprint: www.biorxiv.org/content/10.6...
Reposted by Daniel Trettel
Metal-Triggered Rheological Switching in Engineered Lanmodulin Condensates https://www.biorxiv.org/content/10.64898/2025.12.22.696036v1
December 25, 2025 at 3:46 AM
Metal-Triggered Rheological Switching in Engineered Lanmodulin Condensates https://www.biorxiv.org/content/10.64898/2025.12.22.696036v1
One step closer to designer organelles. Super excited to have been a part of this!
New PrePrint from the Vecchiarelli and Mosalaganti (@shyamalm.bsky.social) labs! 🧵
Collaboration with the Giessen and Pi labs
Congratulations to co-first authors Y Hoang (@hoanghamyy.bsky.social) and Pankaj Jadhav!
www.biorxiv.org/content/10.1...
Collaboration with the Giessen and Pi labs
Congratulations to co-first authors Y Hoang (@hoanghamyy.bsky.social) and Pankaj Jadhav!
www.biorxiv.org/content/10.1...
Engineering Spatial Control of Bacterial Organelles
Bacteria were once thought to lack organelles, but it is now clear they confine cellular reactions using an array of membrane- and protein-based compartments. A central question, however, is how bacte...
www.biorxiv.org
September 26, 2025 at 3:15 PM
One step closer to designer organelles. Super excited to have been a part of this!
Super excited to share our work describing a widespread protein condensation system in bacteria, out in @natcomms.nature.com! We show that encapsulation peptides, from BMCs, independently self-assemble into liquid-like particles. www.nature.com/articles/s41...
A blueprint for biomolecular condensation driven by bacterial microcompartment encapsulation peptides - Nature Communications
Bacteria are increasingly known to employ internal organization strategies. Here, authors demonstrate that bacterial encapsulation peptides cause self-condensation of associated protein domains. These...
www.nature.com
August 13, 2025 at 2:07 PM
Super excited to share our work describing a widespread protein condensation system in bacteria, out in @natcomms.nature.com! We show that encapsulation peptides, from BMCs, independently self-assemble into liquid-like particles. www.nature.com/articles/s41...
Microcompartments are hard to work with, especially if you’re not one of the lucky groups with a model system. Together with @cellforganized.bsky.social and @hoanghamyy.bsky.social, we developed a toolkit for expressing alpha-carboxysomes. Don’t stress it, express it! pubs.acs.org/doi/10.1021/...
Robust Synthetic Biology Toolkit to Advance Carboxysome Study and Redesign
Carboxysomes are polyhedral protein organelles that microorganisms use to facilitate carbon dioxide assimilation. They are composed of a modular protein shell that envelops an enzymatic core mainly co...
pubs.acs.org
June 9, 2025 at 3:25 PM
Microcompartments are hard to work with, especially if you’re not one of the lucky groups with a model system. Together with @cellforganized.bsky.social and @hoanghamyy.bsky.social, we developed a toolkit for expressing alpha-carboxysomes. Don’t stress it, express it! pubs.acs.org/doi/10.1021/...
My favorite work yet! And, it came out on my birthday! Even in grad school, I knew encapsulation peptides were underappreciated. I’m thrilled to have helped give these misunderstood domains a deeper look.
A blueprint for biomolecular condensation driven by bacterial microcompartment encapsulation peptides https://www.biorxiv.org/content/10.1101/2024.11.13.623409v1
A blueprint for biomolecular condensation driven by bacterial microcompartment encapsulation peptides https://www.biorxiv.org/content/10.1101/2024.11.13.623409v1
Bacterial microcompartments (BMC) are protein organelles with diverse metabolic capabilities. Their
www.biorxiv.org
November 15, 2024 at 2:36 AM
My favorite work yet! And, it came out on my birthday! Even in grad school, I knew encapsulation peptides were underappreciated. I’m thrilled to have helped give these misunderstood domains a deeper look.
Is it less weird here?
November 15, 2024 at 2:24 AM
Is it less weird here?