Daniel R. Cuesta-Aguirre
LightNews LightNews
banner
dani96ra.bsky.social
Daniel R. Cuesta-Aguirre
@dani96ra.bsky.social
68 followers 120 following 6 posts
PhD student in ancient populations genomics at the Universitat Autònoma de Barcelona
Posts Replies Media Videos
dani96ra.bsky.social
5/ We hope this tool will help the aDNA community tackle challenges in analyzing degraded mtDNA samples and push the field forward!

👉 Read the full article here: doi.org/10.1111/1755...

#AncientDNA #MolecularEcology #OpenScience
A Post‐Mortem Molecular Damage Profile in the Ancient Human Mitochondrial DNA
Mitochondrial DNA (mtDNA) analysis is crucial for understanding human population structure and genetic diversity. However, post-mortem DNA damage poses challenges, that make analysis difficult. DNA p...
doi.org
January 10, 2025 at 11:05 AM
dani96ra.bsky.social
4/ A huge thank you to my co-authors @crisamorjimenez.bsky.social, and @cmpereirasantos.bsky.social! 🙌
January 10, 2025 at 11:05 AM
dani96ra.bsky.social
3/ We compared the damage profile with mutational hotspots and heteroplasmic positions and found that 2,781 positions had not been previously reported in any of those profiles.
January 10, 2025 at 11:05 AM
dani96ra.bsky.social
2/ Using 427 non-UDG-treated ancient samples from NGS data, we created a comprehensive molecular damage profile for ancient mtDNA, identifying 2,933 damage hotspots across the human mitogenome (out of 11,735 evaluated positions).
Distribution of the 2933 hotspots identified in the present study. These hotspots exhibit a percentage exceeding 23.8% and collectively represent the top 25% of the positions with the highest values. The non-coding region is highlighted in red, while an orange line denotes the origin of replication. Region of the mitogenome with < 30 reads covering them in at least 75% (321 samples) of those analysed are shaded in blue to indicate their absence in our profile.
January 10, 2025 at 11:05 AM