Two years of sustained CR in humans positively affected skeletal muscle quality, and impacted gene expression and splicing profiles of biological pathways known to affected by CR in model organisms. ...

Using samples and data from the CALERIE study, a human randomized controlled trial of long-term caloric restriction, the authors find that the intervention slows DunedinPACE, a DNA methylation measure...

Abstract. Calorie restriction (CR) increases healthy life span and is accompanied by slowing or reversal of aging-associated DNA methylation (DNAm) changes

Methods to quantify biological aging are emerging as new measurement tools for epidemiology and population science and have been proposed as surrogate measures for healthy lifespan extension in gerosc...

Abstract. Biological aging measures have been proposed as proxies for extension of healthy life span in trials of geroprotective therapies that aim to slow

2 years of moderate calorie restriction significantly reduced multiple cardiometabolic risk factors in young, non-obese adults. These findings suggest the potential for a substantial advantage for cardiovascular health of practicing moderate calorie restriction in young and middle-aged healthy individuals, and they offer promise for pronounced long-term population health benefits.

AbstractBackground. Caloric restriction (CR), energy intake reduced below ad libitum (AL) intake, increases life span in many species. The implications for

AgingResearchBiobank provides a state-of-the-art inventory system for the storage and distribution of NIA collections to the broader scientific community.