Damien Glon
@damien-glon.bsky.social
Associate Professor at Paris-Saclay University and Institute for Integrative Biology of the Cell 🇫🇷
Team « Autophagy and Antiviral Immunity »
Virologist interested in biomolecular condensates induced by viral infections 🦠
Team « Autophagy and Antiviral Immunity »
Virologist interested in biomolecular condensates induced by viral infections 🦠
🚨Proud to share the preprint from my postdoc in Yves Gaudin’s lab, in collab with Frédéric Rieux-Laucat’s lab.
🧠Our key finding? NAP1 plays a dual role in regulating innate immunity.
📌This work highlights how phase separation modulates antiviral responses and explains some interferonopathies.
🔗⬇️
🧠Our key finding? NAP1 plays a dual role in regulating innate immunity.
📌This work highlights how phase separation modulates antiviral responses and explains some interferonopathies.
🔗⬇️
NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates
TBK1 kinase is a central regulator of type I IFN production. Upon activation of the IFN-β induction pathway, TBK1-adaptor proteins (NAP1, SINTBAD, TANK) form condensates with liquid properties. We sho...
www.biorxiv.org
May 28, 2025 at 6:17 AM
🚨Proud to share the preprint from my postdoc in Yves Gaudin’s lab, in collab with Frédéric Rieux-Laucat’s lab.
🧠Our key finding? NAP1 plays a dual role in regulating innate immunity.
📌This work highlights how phase separation modulates antiviral responses and explains some interferonopathies.
🔗⬇️
🧠Our key finding? NAP1 plays a dual role in regulating innate immunity.
📌This work highlights how phase separation modulates antiviral responses and explains some interferonopathies.
🔗⬇️
Reposted by Damien Glon
NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates https://www.biorxiv.org/content/10.1101/2025.05.21.655319v1
May 27, 2025 at 8:16 AM
NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates https://www.biorxiv.org/content/10.1101/2025.05.21.655319v1
Reposted by Damien Glon
Ces recherches ont notamment impliqué des scientifiques de l'Institut de biologie intégrative de la cellule (@i2bcparissaclay.bsky.social - @cea.fr / @cnrs.fr / @univparissaclay.bsky.social / @inrae-france.bsky.social / @inserm.fr), situé à Gif-sur-Yvette (Essonne).
@cnrsbiologie.bsky.social
@cnrsbiologie.bsky.social
March 21, 2025 at 8:23 AM
Ces recherches ont notamment impliqué des scientifiques de l'Institut de biologie intégrative de la cellule (@i2bcparissaclay.bsky.social - @cea.fr / @cnrs.fr / @univparissaclay.bsky.social / @inrae-france.bsky.social / @inserm.fr), situé à Gif-sur-Yvette (Essonne).
@cnrsbiologie.bsky.social
@cnrsbiologie.bsky.social